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Concomitant Gastroparesis Negatively Affects Children With Functional Gallbladder Disease

Chumpitazi, Bruno P.*; Malowitz, Stanton M.*; Moore, Warren; Gopalakrishna, G.S.*; Shulman, Robert J.*

Journal of Pediatric Gastroenterology & Nutrition: June 2012 - Volume 54 - Issue 6 - p 776–779
doi: 10.1097/MPG.0b013e3182455cf9
Original Articles: Gastroenterology

Objectives: The aim of the present study was to determine whether concomitant gastroparesis and biliary dyskinesia (BD) occur in children, and if so, to determine whether concomitant gastroparesis affects clinical outcome in children with BD.

Methods: We conducted a retrospective chart review of children with BD (ejection fraction <35% on cholescintigraphy, with no other metabolic or structural cause) who completed a solid-phase gastric emptying scintigraphy scan within 12 months of abnormal cholescintigraphy. Children were classified into 1 of 4 clinical outcome groups (excellent, good, fair, poor).

Results: Thirty-five children with a mean follow-up time of 23.1 ± 17.3 (standard deviation) months were included. Twenty (57%) children were identified as having concomitant gastroparesis (GP) with BD. Children with concomitant GP were more likely to have a poor clinical outcome compared with those with BD alone (P < 0.005). In children undergoing cholecystectomy, those with concomitant GP were more likely to have a fair or poor clinical outcome compared with those with BD alone (P < 0.01). Factors predicting a more favorable clinical outcome were having BD alone and not having limitations in activity (eg, school absences) at the time of presentation.

Conclusions: Concomitant GP may occur in children with functional gallbladder disorders. Concomitant GP may negatively affect clinical outcome in children with BD.

*Department of Pediatrics, Baylor College of Medicine

Texas Children's Hospital, Houston, TX.

Address correspondence and reprint requests to Bruno P. Chumpitazi, MD, MPH, Texas Children's Hospital, 6701 Fannin St, CCC 1010.03, Houston, TX 77030 (e-mail:

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Received 2 April, 2011

Accepted 4 November, 2011

The authors received support in part from the Texas Medical Center Digestive Disease Center (National Institutes of Health DK-58338) and the NASPGHAN Foundation/Nestle Nutrition Young Investigator Development Award (B.P.C.).

The authors report no conflicts of interest.

Copyright 2012 by ESPGHAN and NASPGHAN