Objectives: There are limited data on health-related quality of life (HRQOL) in pediatric patients with long-standing pancreatitis (including acute relapsing and chronic pancreatitis) using age-appropriate measurement instruments.
Methods: We evaluated HRQOL in children with long-standing pancreatitis using the PedsQL 4.0 Generic Core Scales by patient self-report as well as parent proxy report. Additionally, patient self-reports and parent proxy reports were completed for the PedsQL Multidimensional Fatigue Scale.
Results: Across all of the dimensions, significantly impaired HRQOL and higher fatigue were noted for both pediatric patient self-report and parent proxy report in comparison with the matched healthy children samples. Higher fatigue was associated with lower HRQOL. There was moderate to good agreement between patient self-reports and parent proxy reports.
Conclusions: Given the impaired HRQOL and fatigue documented in the present study, future studies are needed to determine whether specific factors can modify HRQOL and fatigue in this patient population.
*Division of Pediatric Gastroenterology, Primary Children's Medical Center, University of Utah, Salt Lake City, UT
†Department of Psychology and Neuroscience, Baylor University, Waco, TX
‡Division of Pediatric Surgery, Primary Children's Medical Center, University of Utah, Salt Lake City, UT
§Department of Pediatrics, College of Medicine, Texas A&M University, College Station, TX.
Address correspondence and reprint requests to John F. Pohl MD, Associate Professor of Pediatrics, Department of Pediatric Gastroenterology, Primary Children's Medical Center, University of Utah, 100 N Mario Capecchi Dr, Suite 2650, Salt Lake City, UT 84113-1103, (e-mail: email@example.com).
Received 29 June, 2011
Accepted 10 October, 2011
This research was funded by Aptalis Pharma (Bridgewater, NJ). J.F.P. and J.W.V. have received investigator-initiated funding from Takeda Pharmaceuticals (Deerfield, IL). J.W.V. holds the copyright and the trademark for the PedsQL and receives financial compensation from the Mapi Research Trust, which is a nonprofit research institute that charges distribution fees to for-profit companies that use the Pediatric Quality of Life Inventory. The other authors report no conflicts of interest.