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Feasibility and Efficacy of Transjugular Intrahepatic Portosystemic Shunt (TIPS) in Children

Di Giorgio, Angelo*; Agazzi, Roberto; Alberti, Daniele; Colledan, Michele§; D’Antiga, Lorenzo*

Journal of Pediatric Gastroenterology & Nutrition: May 2012 - Volume 54 - Issue 5 - p 594–600
doi: 10.1097/MPG.0b013e3182490c05
Original Articles: Hepatology and Nutrition

Objectives: Transjugular intrahepatic portosystemic shunt (TIPS) is a valuable tool in managing complications of severe portal hypertension (PH) in adults. In children, TIPS is regarded as a temporary and technically demanding procedure. We report the first paediatric series of TIPS and review its feasibility and efficacy in children.

Methods: Children with severe PH that is unresponsive to nonselective β-blockers and endoscopic treatment were considered candidates for TIPS placement with an expanded polytetrafluoroethylene-covered Viatorr stent graft. Indications were cirrhotic PH, noncirrhotic PH, and portal vein thrombosis, in both native and transplanted livers.

Results: Thirteen children were selected for TIPS between 2005 and 2010. The indications were bleeding in 8 (61.5%) and ascites in 5 (38.5%). TIPS was successfully placed in 11 children, median age 9.8 years (range 2.2–18) and median weight 30 kg (11.5–96). Two patients had a portal cavernoma and 3 had received split liver transplantation. Following TIPS, the portosystemic gradient decreased to 10 mmHg (5–15 mmHg) (P < 0.00001); PH complications resolved in 10 of 11 patients (91%); no patient developed clinical encephalopathy; and 3 patients required a TIPS revision. All of the shunts were patent at last follow-up (20.4 months, range 0.2–67) in 7 or liver transplantation (6 months, 1.5–33) in 4.

Conclusions: Our results suggest that TIPS is feasible and effective in children with ascites or gastrointestinal bleeding unresponsive to medical and endoscopic treatment. TIPS should become part of the armamentarium that is used to manage PH complications in children, both in native livers and in transplanted grafts, as a bridge to transplantation and for long-term management.

*Paediatric Hepatology, Gastroenterology and Transplantation

Interventional Radiology

Paediatric Surgery

§Department of Surgery, Ospedali Riuniti di Bergamo, Bergamo, Italy.

Address correspondence and reprint requests to Dr Lorenzo D’Antiga, Paediatric Hepatology, Gastroenterology and Transplantation, Ospedali Riuniti di Bergamo, Largo Barozzi 1, 24128 Bergamo, Italy (e-mail: ldantiga@ospedaliriuniti.bergamo.it).

Received 3 October, 2011

Accepted 29 November, 2011

The authors report no conflicts of interest.

Copyright 2012 by ESPGHAN and NASPGHAN