Skip Navigation LinksHome > December 2011 - Volume 53 - Issue 6 > Biochemical Parameters and Anthropometry Predict NAFLD in Ob...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e31822960be
Short Communication

Biochemical Parameters and Anthropometry Predict NAFLD in Obese Children

Maffeis, Claudio*; Banzato, Claudia*; Rigotti, Francesca*; Nobili, Valerio; Valandro, Silvia*; Manfredi, Riccardo; Morandi, Anita*

Supplemental Author Material
Collapse Box


ABSTRACT: The aim of the present study was to build a predictive model of nonalcoholic fatty liver disease (NAFLD) in obese children. Fifty-six obese 10-year-old children underwent blood tests for biochemical measures and magnetic resonance imaging for NAFLD diagnosis. A model combining waist-to-height ratio, homeostasis model assessment of insulin resistance, adiponectin, and alanine aminotransferase was accurate in predicting NAFLD (AUROC = 0.94 [95% confidence interval 0.89–0.99], P < 10−5). When adiponectin was not included in the model, the discrimination accuracy was still good (AUROC = 0.88 [95% confidence interval 0.79–0.97], P < 10−5). In conclusion, a predictive equation combining routinely available variables may allow physicians to identify obese children at the highest risk of NAFLD.

Copyright 2011 by ESPGHAN and NASPGHAN


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us