Skip Navigation LinksHome > November 2011 - Volume 53 - Issue 5 > Immunogenicity of Hepatitis A Vaccine in Children With Celia...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e318223b3ed
Original Article: Hepatology and Nutrition

Immunogenicity of Hepatitis A Vaccine in Children With Celiac Disease

Sari, Sinan*; Dalgic, Buket*; Basturk, Bilkay; Gonen, Sevim; Soylemezoglu, Oguz

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Objectives: The response to hepatitis A vaccine has not been studied in children with celiac disease (CD). The aim of the present study was to evaluate the immunogenicity of an inactivated hepatitis A virus (HAV) vaccine and the effect of the human leukocyte antigen (HLA) type on immunogenicity in children with CD.

Patients and Methods: Thirty-three patients with CD and 62 healthy controls were enrolled in the study. Inactivated HAV vaccine (Havrix; GlaxoSmithKline Biologicals, Rixensart, Belgium) containing 720 enzyme-linked immunosorbent assay units of alum-adsorbed hepatitis A antigen was administered intramuscularly in a 2-dose schedule at 0 and 6 months. Seroconversion rates and antibody titers of HAV were measured at 1 and 7 months.

Results: At 1 month, seroconversion rates were 78.8% and 77.4% and geometric mean titers were 50.7 and 49.9 mIU/mL in the CD and control groups, respectively (P > 0.05). At 7 months, seroconversion rates were 97% and 98.4% and geometric mean titers were 138.5 and 133 mIU/mL in the CD and control groups, respectively (P > 0.05). The most frequent HLA types were HLA-DQ2, -DR3, and -DR7 alleles in patients with CD and HLA-DQ3, -DQ6, -DR11, and -DR14 in the controls. There was no association between HLA alleles and antibody titers of hepatitis A vaccine.

Conclusion: Children with CD have a good immune response to hepatitis A vaccine, similar to healthy controls.

Copyright 2011 by ESPGHAN and NASPGHAN


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