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Zinc Monotherapy From Time of Diagnosis for Young Pediatric Patients With Presymptomatic Wilson Disease

Mizuochi, Tatsuki*; Kimura, Akihiko*; Shimizu, Norikazu; Nishiura, Hiroshi*; Matsushita, Masami*; Yoshino, Makoto*

Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e31821d5abe
Short Communications
Abstract

ABSTRACT: In 4 young pediatric patients with presymptomatic Wilson disease, we found zinc monotherapy beginning at time of diagnosis to be safe and highly effective for follow-up intervals between 1 and 2 years. Such maintenance therapy with zinc can maintain urinary copper excretion between 1 and 3 μg · kg−1 · day−1.

Author Information

*Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume

Department of Pediatrics, Toho University School of Medicine, Ohashi Medical Center, Tokyo, Japan.

Address correspondence and reprint requests to Akihiko Kimura, MD, PhD, Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume-shi 830-0011, Japan (e-mail: hirof@med.kurume-u.ac.jp).

Received 6 October, 2010

Accepted 25 March, 2011

The authors report no conflicts of interest.

Copyright 2011 by ESPGHAN and NASPGHAN