ABSTRACT: In 4 young pediatric patients with presymptomatic Wilson disease, we found zinc monotherapy beginning at time of diagnosis to be safe and highly effective for follow-up intervals between 1 and 2 years. Such maintenance therapy with zinc can maintain urinary copper excretion between 1 and 3 μg · kg−1 · day−1.
*Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume
†Department of Pediatrics, Toho University School of Medicine, Ohashi Medical Center, Tokyo, Japan.
Address correspondence and reprint requests to Akihiko Kimura, MD, PhD, Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume-shi 830-0011, Japan (e-mail: firstname.lastname@example.org).
Received 6 October, 2010
Accepted 25 March, 2011
The authors report no conflicts of interest.