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Celiac Disease in Children With Diarrhea in 4 Cities in China

Wang, Xin-qiong*; Liu, Wei*; Xu, Chun-di*; Mei, Hong; Gao, Yuan; Peng, Han-ming; Yuan, Lan§; Xu, Jun-jie

Journal of Pediatric Gastroenterology & Nutrition: October 2011 - Volume 53 - Issue 4 - p 368–370
doi: 10.1097/MPG.0b013e31822a0128
Invited Review

Objective: The aim of the study was to investigate whether celiac disease (CD) could be the cause of chronic diarrhea in Chinese patients.

Patients and Methods: During the period of January 2005 to December 2008, patients with chronic diarrhea in pediatric hospitals from 4 major cities (Shanghai, Wuhan, Jinan, and Chengdu) in China were included in the study. The clinical history, physical findings, and laboratory data were collected and analyzed.

Results: Among 199 patients with chronic diarrhea, 118 were enrolled in the study. Fourteen (11.9%) were diagnosed as being affected by CD.

Conclusions: The 14 patients are the first reported cases of CD in Chinese patients with chronic diarrhea.

*Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

Department of Gastroenterology, Qilu Children's Hospital, Shandong University, Jinan, Shandong

Department of Gastroenterology, Wuhan Children's Hospital, Wuhan, Hubei

§Department of Gastroenterology, Chengdu Children's Hospital, Chengdu, Sichuan, China.

Address correspondence and reprint requests to Xu Chun-di, Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (e-mail:

Received 16 July, 2010

Accepted 19 April, 2011

The present study is partly supported by the IPSEN Fund.

The authors report no conflicts of interest.

Copyright 2011 by ESPGHAN and NASPGHAN