Objectives: The aim of the study was to assess the efficacy of gastrostomy tube (GT) placement on improving nutritional status and pulmonary function in patients with cystic fibrosis (CF).
Patients and Methods: Data were collected from the Minnesota Cystic Fibrosis Database. Subjects with at least 5 percent-predicted forced expiratory volume in 1 second (ppFEV1) and 1 BMI percentile (pBMI) measurements before and after GT placement were included. Median pBMI values were compared 2 years before and 1, 2, and 4 years after GT placement using a signed rank test. Longitudinal mixed model analysis was used to assess the effect of GT placement on ppFEV1. To assess the effect of ppFEV1 at GT placement on efficacy, the estimated ppFEV1 change was regressed against the ppFEV1 level at placement.
Results: Forty-six subjects with CF who met entry criteria were identified. Mean estimated step changes in ppFEV1 at placement for men, women, boys, and girls were 2.16% (P = 0.52), 0.43% (P = 0.92), 0.99% (P = 0.65), and −0.91% (P = 0.74), respectively. Mean estimated slope changes of ppFEV1 after GT placement were 5.01% (P = 0.02), 4.48% (P = 0.07), 1.49% (P = 0.23), and 4.02% (P = 0.01) per year for men, women, boys, and girls, respectively. Median change in pBMI in the second year after GT placement was 13.3% (P ≤ 0.0001). Estimated coefficients for the effect of ppFEV1 level at placement on the ppFEV1 step and slope change were −0.041 (P = 0.28) and −0.005 (P = 0.84), respectively.
Conclusions: GT placement in patients with CF results in significant improvement in both pBMI and ppFEV1, except in women. The change in lung function after GT placement is not dependent on the level of lung function at placement.
*Rocky Mountain Pediatric Gastroenterology, Denver, CO
†Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, School of Medicine
‡Department of Pediatrics, Division of Pediatric Pulmonology
§Department of Internal Medicine, Division of Pulmonology
||Minnesota Cystic Fibrosis Center, School of Medicine, University of Minnesota, Minneapolis, MN.
Address correspondence and reprint requests to Sarah J. Schwarzenberg, MD, Division of Pediatric Gastroenterology and Nutrition, University of Minnesota, East Building, 6th Floor, 2450 Riverside AV, Minneapolis, MN 55454 (e-mail: firstname.lastname@example.org).
Received 10 September, 2010
Accepted 18 May, 2011
This article was supported, in part, by a Clinical Fellowship from the Cystic Fibrosis Foundation (C.B.) and by the Minnesota Cystic Fibrosis Center.
The authors report no conflicts of interest.