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Two-day Bowel Preparation With Polyethylene Glycol 3350 and Bisacodyl: A New, Safe, and Effective Regimen for Colonoscopy in Children

Phatak, Uma P; Johnson, Susanne; Husain, Sohail Z; Pashankar, Dinesh S

Journal of Pediatric Gastroenterology & Nutrition: July 2011 - Volume 53 - Issue 1 - p 71–74
doi: 10.1097/MPG.0b013e318210807a
Original Articles: Gastroenterology

Objectives: To assess the safety, efficacy, and acceptance of a 2-day bowel preparation with polyethylene glycol (PEG) 3350 without electrolytes and bisacodyl for colonoscopy in children.

Patients and Methods: In a prospective study, 111 children of mean age 11.9 years were given 2 g/kg of PEG and a 5-mg tablet of bisacodyl daily for 2 days before colonoscopy. Stool frequency, consistency, and adverse effects were monitored for the duration of the bowel preparation. Compliance and quality of colonic preparation were assessed on the day of the colonoscopy.

Results: The average daily stool frequency increased from a baseline of 2, to 4* on day 1, and 6.5* on day 2 of the bowel preparation (*P < 0.001 for difference vs baseline). The colonic preparations were rated as excellent or good in 92% and 93% of the patients in the right and left colon, respectively. Adverse effects were mild nausea (19%), abdominal pain (11%), and vomiting (4%). The compliance was rated as excellent in 95% of the patients.

Conclusions: A 2-day bowel preparation with PEG and bisacodyl is safe, effective, and well accepted for colonoscopy in children without any major adverse effects.

From the Division of Gastroenterology, Department of Pediatrics, Yale University, New Haven, CT, USA.

Received 17 September, 2010

Accepted 14 January, 2011

Address correspondence and reprint requests to Dinesh S. Pashankar, MD, Associate Professor of Pediatrics, Division of Gastroenterology, Yale University, Cedar Street FMP 408, New Haven, CT 06520 (e-mail:

The authors report no conflicts of interest.

Copyright 2011 by ESPGHAN and NASPGHAN