Safety and Efficacy of High-dose Acarbose Treatment for Dumping Syndrome

De Cunto, Angela; Barbi, Egidio; Minen, Federico; Ventura, Alessandro

Journal of Pediatric Gastroenterology & Nutrition: July 2011 - Volume 53 - Issue 1 - p 113–114
doi: 10.1097/MPG.0b013e31820ae6d1
Short Communications

Dumping syndrome (DS) is a complication of Nissen fundoplication. Dietary strategies can ameliorate symptoms, but this approach is not always foolproof. Limited evidence reports the efficacy of acarbose for children who are unresponsive to feeding manipulations. We report 8 patients with DS aged between 7 and 24 months. In 4 of 8 nutritional strategies failed, and acarbose treatment was started. The initial dose was 25 mg for meals, and increased until postprandial glucose was stable. In 3 of 4 children the final dose was higher than previously reported, without adverse effects. Acarbose is useful to treat DS in cases of failure of dietary strategies.

Department of Pediatrics, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy.

Received 17 September, 2010

Accepted 10 December, 2010

Address correspondence and reprint requests to Angela De Cunto, Via dell'Istria 67/1, 34100 Trieste, Italy (e-mail: angela.decunto@libero.it).

The authors report no conflicts of interest.

Copyright 2011 by ESPGHAN and NASPGHAN