Skip Navigation LinksHome > July 2011 - Volume 53 - Issue 1 > Leukocytapheresis in Pediatric Patients With Ulcerative Coli...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e31821058bc
Original Articles: Gastroenterology

Leukocytapheresis in Pediatric Patients With Ulcerative Colitis

Tomomasa, Takeshi*; Tajiri, Hitoshi; Kagimoto, Seiichi; Shimizu, Toshiaki§; Yoden, Atsushi||; Ushijima, Kosuke; Uchida, Keiichi#; Kaneko, Hiroaki**; Abukawa, Daiki††; Konno, Mutsuko‡‡; Maisawa, Shun-ichi§§; Kohsaka, Takao||||; Kobayashi, Akio¶¶; and the Japanese Study Group for Pediatric Ulcerative Colitis

Collapse Box


Objective: Leukocytapheresis (LCAP) is a nonpharmacologic therapy that has recently been used to treat ulcerative colitis (UC). This multicenter open-label study prospectively assessed the efficacy and safety of LCAP in pediatric patients with UC.

Patients and Methods: Twenty-three patients ages 8 to 16 years with moderate (n = 19) to severe (n = 4) steroid-resistant UC were enrolled. One of 2 LCAP columns with different volumes (model EX and the half-volume model EI) was selected, according to body weight. LCAP was performed once per week for 5 consecutive weeks. Clinical and laboratory data were collected at predetermined time points. The primary endpoint was decreased stool frequency/hematochezia score, and secondary endpoints were clinical, laboratory, and endoscopic improvements.

Results: The stool frequency/hematochezia score decreased significantly from 4.5 ± 1.2 before treatment to 1.6 ± 1.9 after the fifth treatment. Clinical parameters, including stool frequency, presence of visible blood, abdominal pain, and body temperature, were significantly improved. Fecal calprotectin decreased significantly. Endoscopic findings evaluated using Matts score also improved (P < 0.01). The steroid dose decreased from 1.1 ± 0.4 mg/kg before treatment to 0.8 ± 0.5 mg/kg after treatment. There were no significant differences in changes between the EX and EI columns. The incidence of adverse effects was 61%, although none was serious. The most common adverse effects were decreased hematocrit and hemoglobin concentration.

Conclusions: The present study showed that LCAP was well tolerated in children with UC, mostly moderate, and was as effective as in adults. The types of pediatric patients best suited to LCAP remain to be determined.

Copyright 2011 by ESPGHAN and NASPGHAN


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us