We investigated the performance of aspartate aminotransferase to platelet ratio index (APRI) as a noninvasive marker of fibrosis and cirrhosis in children with chronic viral hepatitis. All of the patients 0 to 20 years old with chronic hepatitis B or C presenting at a tertiary medical center from 1992 to 2008 were identified. Thirty-six patients were evaluated with 48 biopsy results. The areas under the receiver operating characteristic curve were 0.71 for fibrosis and 0.52 for cirrhosis. When examining subgroups, the APRI performed better in older patients and in those with vertically transmitted hepatitis C virus. Further research into APRI and the other noninvasive markers of fibrosis in children with chronic viral hepatitis is warranted.
*Department of Pediatrics, USA
†Divisions of Quantitative Sciences, USA
§Infectious Diseases, USA
||Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, NC. At the time of writing, Dr McGoogan was in the DUMC Department of Pediatrics; she is now in the Department of Pediatrics, Division of Gastroenterology, University of Florida, Gainesville, USA.
Received 14 January, 2009
Accepted 11 May, 2009
Address correspondence and reprint requests to Ravi Jhaveri, MD, Division of Pediatric Infectious Diseases, DUMC Box 3499, Duke University Medical Center, Durham, NC 27710 (e-mail: firstname.lastname@example.org).
The authors report no conflicts of interest.