You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Prognosis of Chronic or Recurrent Abdominal Pain in Children

Gieteling, Marieke J*; Bierma-Zeinstra, Sita MA*; Passchier, Jan; Berger, Marjolein Y*

Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e31815bc1c1
Original Articles: Gastroenterology

Background: Chronic abdominal pain (CAP) or recurrent abdominal pain is common in childhood and is rarely associated with organic disease. With modern diagnostic technology, new organic abnormalities are found in children with CAP. Thus far a causal relation between these abnormalities and CAP has not been established. The additional prognostic value of extensive testing of children with CAP is a subject of debate.

Objectives: To investigate how often abdominal pain persists in children with CAP and to investigate whether medical tests such as laboratory tests, imaging, and endoscopy have additional prognostic value to history taking and clinical examination.

Materials and Methods: A systematic search was conducted in MEDLINE, EMBASE, and PsycINFO for prospective cohort studies published from 1960 until October 2005. The most common medical key words for CAP were used in our search strategy. The methodological quality of studies was determined. Clinical heterogeneity between studies was analyzed. The percentages of children with abdominal pain after follow-up were pooled.

Results: The search yielded 2620 citations, of which 18 studies met the inclusion criteria. In total, 1331 children were followed up for 5 years (median, range 1–29 years). In total, 29.1% (95% CI 28.1–30.2) of patients with CAP had abdominal pain after follow-up. The prognosis of CAP diagnosed clinically was similar to that diagnosed after additional medical testing.

Conclusions: CAP persisted in 29.1% (95% CI 28.1–30.2) of children. In the absence of alarming symptoms, additional diagnostic testing did not influence the prognosis of CAP.

Author Information

*Department of General Practice, The Netherlands

Department of Medical Psychology and Psychotherapy, Erasmus Medical Centre, Rotterdam, The Netherlands

Received 10 November, 2006

Accepted 17 August, 2007

Address correspondence and reprint requests to Dr Marieke J. Gieteling, Department of General Practice, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands (e-mail:

The authors report no conflicts of interest.

© 2008 Lippincott Williams & Wilkins, Inc.