Skip Navigation LinksHome > October 2007 - Volume 45 - Issue 4 > Cryptosporidium Infection in Patients With Primary Immunodef...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e318054b09b
Original Articles: Hepatology and Nutrition

Cryptosporidium Infection in Patients With Primary Immunodeficiencies

Wolska-Kusnierz, Beata*; Bajer, Anna; Caccio, Simone; Heropolitanska-Pliszka, Edyta*; Bernatowska, Ewa*; Socha, Piotr*; van Dongen, Jacques§; Bednarska, Malgorzata; Paziewska, Anna; Sinski, Edward

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Background: Cryptosporidium species infection is usually self-limited in immunocompetent populations, but can be severe and life-threatening among immunocompromised individuals, particularly in patients with AIDS and in these patients with primary immunodeficiencies (PIDs).

Patients and Methods: A group of 5 patients with genetically confirmed hyper-IgM syndrome type 1 (XHIM) and one patient with primary CD4 lymphopenia were enrolled in the study. At least 2 stool samples and a bile sample in one patient were examined for Cryptosporidium oocysts by a modified Ziehl-Neelsen technique, by immunofluorescence assay using a commercial kit, as well as by molecular analysis followed by genotyping. Immunological status at the time of PID diagnosis and the complex picture of disease are presented.

Results: Chronic cryptosporidiosis was confirmed in 3 patients with XHIM and in one patient with primary CD4 lymphopenia. Molecular diagnosis showed the presence of C parvum, C hominis, and C meleagridis in analyzed specimens.

Conclusions: Cryptosporidium infection with serious clinical symptoms observed in patients with hyper-IgM syndrome calls for regular, repeated screening in this group of patients.

© 2007 Lippincott Williams & Wilkins, Inc.


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