Skip Navigation LinksHome > September 2007 - Volume 45 - Issue 3 > Subclinical Neurological Abnormalities in Children With Celi...
Journal of Pediatric Gastroenterology & Nutrition:
doi: 10.1097/MPG.0b013e31806907e8
Short Communication

Subclinical Neurological Abnormalities in Children With Celiac Disease Receiving a Gluten-free Diet

Cakir, D*; Tosun, A; Polat, M; Celebisoy, N; Gokben, S; Aydogdu, S; Yagci, RV; Tekgul, H

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Objectives: Because clinically evident manifestations are frequent in adults with celiac disease (CD), we aimed to investigate whether early neurological abnormalities may be detected in children with CD.

Methods: Electroencephalography, electromyography, and somatosensory evoked potentials were performed in children with CD receiving a gluten-free diet.

Results: The neurophysiological tests revealed subclinical neurological abnormalities associated with CD in 3 (11%) of 27 children: 2 had peripheral polyneuropathy documented with electromyography, and 1 had prolonged latencies in somatosensory evoked potential. Magnetic resonance imaging showed abnormalities in 2 (7.4%) of children: pontine demyelinization in 1 and cortical atrophy in the other.

Conclusions: Because the rate of neurological problems is increased in children with CD, neurological abnormalities should be carefully investigated early after the diagnosis of CD is made.

© 2007 Lippincott Williams & Wilkins, Inc.


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