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Immunoreactive Ghrelin in Human Cord Blood: Relation to Anthropometry, Leptin, and Growth Hormone

Chanoine, Jean-Pierre*; Yeung, Louisa PK*; Wong, Alfred CK*; Birmingham, Carl Laird†

Journal of Pediatric Gastroenterology & Nutrition: September 2002 - Volume 35 - Issue 3 - pp 282-286
Original Articles: Nutrition

Background: Ghrelin is secreted by the stomach, the hypothalamus, and the placenta in humans and has growth hormone–secreting and orexigenic properties. Leptin is secreted mainly by the adipocyte, plays a major role in energy balance, and reflects fat mass in infants as well as adults. Leptin and ghrelin central effects are mediated, at least partly, through the neuropeptide Y/Y1 receptor pathway in the hypothalamus.

Methods: We determined whether ghrelin is also present in the fetus and investigated its relationship to leptin, growth hormone, birth weight, and calf and abdominal circumferences in 90 full-term neonates.

Results: Immunoreactive ghrelin was detected in all cord samples (mean ± SD, 187 ± 88 pmol/L; range, 66—594 pmol/L). In contrast to leptin, ghrelin concentrations of boys and girls were not statistically different. In female neonates, ghrelin is inversely correlated with anthropometric measures. In male neonates, ghrelin is positively correlated with leptin and negatively with growth hormone.

Conclusion: The presence of significant ghrelin concentrations in all neonates before the first feeding is intriguing. Unlike the fairly constant concentrations and effects of leptin over the short term, the wide variability of ghrelin concentrations observed in newborns raises the possibility that ghrelin secretion causes short-term changes in feeding behavior. We suggest that ghrelin may play a physiologic role in the initiation of feeding.

*Endocrinology and Diabetes Unit, British Columbia's Children's Hospital, †Eating Disorders Clinic, St. Paul's Hospital, Vancouver, Canada

Received November 20, 2001; accepted May 2, 2002.

Address correspondence and reprint requests to Dr. Jean-Pierre Chanoine, Endocrinology and Diabetes Unit, Room K4212, British Columbia's Children's Hospital, 4480 Oak Street, Vancouver BC V6H 3V4, Canada (e-mail:

© 2002 Lippincott Williams & Wilkins, Inc.