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Inflammatory Bowel Disease in Infancy: An Increasing Problem?

Dady, Ian M.; Thomas, Adrian G.; Miller, Victor; Kelsey, Anna J.*

Journal of Pediatric Gastroenterology & Nutrition:
Original Article

Summary: Seven children with intractable diarrhoea of infancty seen between 1990 and 1993 developed endoscopically established inflammatory bowel disease unrelated to bacterial infection and not responsive to whole protein exclusion. Mouth ulcers were present in two patients, endoscopic upper-gastrointestinal-tract inflammation in two, villous atrophy in six, and chronic nonspecific colitis in all seven. There was considerable clinical and histological heterogeneity. All patients required parenteral nutrition. Steroid therapy was completely successful in only one child, while two underwent colectomy, and two died. Previously described cases other than those due to infection or milk intolerance have been rare and sporadic. The prevalence of inflammatory bowel disease in infancy is unknown but appears to be increasing.

Author Information

Department of Paediatric Gastroenterology, Booth Hall Childrens' Hospital; and *Department of Histopathology, Royal Manchester Childrens' Hospital, Manchester, England

Address correspondence and reprint requests to Dr. V. Miller, Booth Hall Childrens' Hospital, Charlestown Road, Blackley, Manchester M9 7AA, England.

Manuscript received February 24, 1995; revision received March 29, 1995; accepted November 16, 1995.

© Lippincott-Raven Publishers