Skip Navigation LinksHome > February 1993 - Volume 16 - Issue 2 > Association Between HLA and Extrahepatic Biliary Atresia.
Journal of Pediatric Gastroenterology & Nutrition:
Original Article: PDF Only

Association Between HLA and Extrahepatic Biliary Atresia.

Silveira, Themis R.; Salzano, Francisco M.; Donaldson, Peter T.; Mieli-Vergani, Georgina; Howard, Edward R.; Mowat, Alex P.

Collapse Box

Abstract

Summary: The etiopathogenesis of extrahepatic biliary atresia (EHBA) remains undefined. There are clinical and pathological suggestions supporting the idea that EHBA could consist of at least two forms: the congenital (embryonic or fetal) and the acquired (perinatal) types. To test the hypothesis that susceptibility to this disease would be influenced by host genetic factors, we studied the human leukocyte antigen (HLA) system in 55 patients with and without major extrahepatic congenital anomalies. We found, especially in those without associated malformations, a significantly higher frequency of HLA-B12, of haplotypes A9-B5 and A28-B35, and of their disequilibrium values, as compared with the 8th International Histocompatibility Workshop controls. This study suggests that immunogenetic factors may play a role in determining susceptibility to EHBA, and the different HLA frequencies in those with and without anomalies lend support to the hypothesis that biliary atresia may be an etiologically heterogeneous disorder.

(C) Lippincott-Raven Publishers.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us

 

 

Twitter

twitter.com/JPGNonline

 

Visit JPGN.org on your smartphone. Scan this code (QR reader app required) with your phone and be taken directly to the site.