Mast Cells and Eosinophils in the Jejunal Mucosa of Patients with Intestinal Cow's Milk Allergy and Celiac Disease of Childhood.

Kosnai, I.; Kuitunen, P.; Savilahti, E.; Sipponen, P.
Journal of Pediatric Gastroenterology & Nutrition:
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Abstract

Summary: We counted the number of granulated mast cells with high iron diamine staining, and the number of eosinophils with hematoxyline-eosin staining, in the lamina propria of the jejunum in 12 untreated patients with intestinal cow's milk allergy (CMA), 47 with celiac disease (CD), and 14 controls. A decreased number of mast cells and an increased number of eosinophils were found in 58% of patients with CMA, and in 60% of those with CD. The number of mast cells showed a significant positive correlation with the villous height, and the number of eosinophils a negative correlation with both the villous height, and the number of mast cells. Appropriate dietary treatment resulted in a rise in the number of granulated mast cells and a decrease in the number of eosinophils in both patient groups.

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