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Stanford, E. J.
Gynecology, University of Tennessee, Memphis, TN
DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS: Edward Stanford:Ortho McNeil:Research grant:Researcher
To evaluate perceived response to treatment in patients diagnosed with interstitial cystitis (IC).
A retrospective database review and telephone survey was conducted at a reference Urogynecologic center. The records of 212 confirmed IC patients were identified of which 122 patients completed a telephone survey (58%) to confirm results. Of the 122 patients, 37 (30.3%) had a diagnosis of IC alone, 54 had one concomitant disorder (44.3%) and 31 had >one concomitant disorder (25.3%). Patients were given a list of treatments and were asked to rate which treatment was most effective in relieving their symptoms related to their chronic pelvic pain (CPP) and IC. IRB approval was obtained.
Treatments of interest were diet, pentosan polysulfate (PPS), intravesical heparin, or other (neuromodulation). Cystoscopy with hydrodistension and dimethyl sulfoxide (DMSO) were not offered to this patient cohort. Patients ranked PPS (29.6%), diet with PPS (23.5%), and intravesical heparin with PPS (15.7%) as most helpful in improving their symptoms related to the chronic pelvic pain and IC. Diet alone was judged as helpful in only 5.2%. Despite the fact that 85 patients (69.7%) had IC and concomitant disorders, surgery was not judged as particularly helpful compared to medical therapy in relieving chronic pain symptoms.
Patients with IC with or without concomitant disorders perceive medical therapy with PPS alone, PPS with diet modifications, and PPS with intravesical heparin as most helpful in relieving CPP/IC symptoms. Surgical therapies were judged as less helpful.
Interstitial cystitis; Treatment; Chronic pelvic pain; Heparin; Pentosan polysulfate
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