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Pharmacological Treatment of Urinary Incontinence

Cipullo, Lucio M.A. MD; Zullo, Fulvio MD; Cosimato, Cosimo MD; Di Spiezio Sardo, Attilio MD; Troisi, Jacopo MD; Guida, Maurizio MD

Female Pelvic Medicine & Reconstructive Surgery: July/August 2014 - Volume 20 - Issue 4 - p 185–202
doi: 10.1097/SPV.0000000000000076
Fellows Article

Abstract: We present an overview of the current pharmacological treatment of urinary incontinence (UI) in women, according to the latest evidence available. After a brief description of the lower urinary tract receptors and mediators (detrusor, bladder neck, and urethra), the potential sites of pharmacological manipulation in the treatment of UI are discussed. Each class of drug used to treat UI has been evaluated, taking into account published rate of effectiveness, different doses, and way of administration. The prevalence of the most common adverse effects and overall compliance had also been pointed out, with cost evaluation after 1 month of treatment for each class of drug. Moreover, we describe those newer agents whose efficacy and safety need to be further investigated. We stress the importance of a better understanding of the causes and pathophysiology of UI to ensure newer and safer treatments for such a debilitating condition.

An overview of the pharmacological treatment of urinary incontinence in women and related costs.

From the Department of Gynecology and Obstetrics of San Giovanni di Dio and Ruggi d’Aragona Hospital, University of Salerno, Salerno, SA, Italy.

Reprints: Lucio M.A. Cipullo, MD, University of Salerno, Largo Ippocrate n° 1, 84131 Salerno, SA, Italy. E-mail: luciocipullo@hotmail.com.

The authors have declared they have no conflicts of interest.

© 2014 by Lippincott Williams & Wilkins