Skip Navigation LinksHome > May/June 2014 - Volume 20 - Issue 3 > Perioperative Anticholinergic Medications and Risk of Cathet...
Female Pelvic Medicine & Reconstructive Surgery:
doi: 10.1097/SPV.0000000000000075
AUGS Conference Submissions

Perioperative Anticholinergic Medications and Risk of Catheterization After Urogynecologic Surgery

Walter, Paige J. MBS, MD; Dieter, Alexis A. MD; Siddiqui, Nazema Y. MD, MHSc; Weidner, Alison C. MD; Wu, Jennifer M. MD, MPH

Collapse Box


Objective: This study aimed to examine how anticholinergic medication exposure affects the risk of failed postoperative void trial (VT) in women undergoing urogynecologic surgery.

Methods: We conducted a retrospective cohort study of women undergoing outpatient prolapse or incontinence surgery. We evaluated perioperative anticholinergic exposure via the validated anticholinergic risk scale (ARS). Total ARS score was calculated by summing the individual ARS for each medication used during the following periods: at home before surgery, in preoperative holding, intraoperatively, and in postoperative recovery. The “low anticholinergic exposure” cohort (total ARS, ≤7) was compared to the “high anticholinergic exposure” cohort (total ARS, ≥8) to assess our primary outcome: failed postoperative VT on day of surgery.

Results: Of 125 women in the study, 98 (78%) had low anticholinergic exposure and 27 (22%) had high anticholinergic exposure. Overall, 28 (22%) patients failed the postoperative VT. Women in the high anticholinergic group had a significantly higher risk of a failed VT (41% vs 17%, P = 0.01 for high vs low anticholinergic groups, respectively). In logistic regression analysis, adjusting for age, body mass index, diabetes, midurethral sling and anterior repair, high anticholinergic exposure (AOR, 4.15; 95% confidence interval, 1.49–11.57), and anterior repair (AOR, 3.15; 95% CI, 1.15–8.61) remained significantly associated with failed postoperative VT.

Conclusions: Higher exposure to perioperative anticholinergic medications increases the risk of a failed postoperative VT after outpatient urogynecologic surgery.

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.