Objective: Because of the reported high percentage of bladder infections after placement of a midurethral sling (8.9%–34%), this study was undertaken to determine if a 3-day postoperative course of a urinary antibiotic would significantly lower the incidence of urinary tract infection (UTI) among treated women.
Methods: Women who were planning outpatient vaginal surgery for stress incontinence were enrolled, after informed consent, and randomized to receive placebo or nitrofurantoin (100 mg 2 times a day) for 3 days after surgery. Research subjects and investigators were blinded to the randomization. Women were observed for signs and symptoms of UTI until 6 weeks after surgery. Sample size was calculated to have 80% power to detect a 15% difference in the primary outcome (α = 0.05). The primary outcome was analyzed using a χ2 analysis.
Results: Data were analyzed from 149 subjects (placebo, n = 75; drug, n = 74). Overall, 37 women (24.8%) were diagnosed with a UTI during the study period. The incidence of postoperative UTI was significantly lower in the treatment arm (17.6%) then in the placebo arm (32%; P = 0.04).
Conclusions: A short (3-day) course of nitrofurantoin after outpatient sling surgery significantly reduces the incidence of postoperative bladder infection in the first 6 weeks after sling surgery. (clinicaltrials.gov registration number: NCT00734968).
Postoperative prophylaxis with nitrofurantoin significantly reduces the risk of postoperative urinary tract infection after placement of a midurethral sling.
From the *Department of Obstetrics, Gynecology, and Women’s Health, School of Medicine, University of Missouri, Columbia, MO; and †Department of Obstetrics and Gynecology, Scott and White Hospital, Texas A&M University System Health Sciences Center, Temple, TX.
Reprints: Raymond T. Foster Sr, MD, MS, MHSc, 500 Keene St, Suite 306, Columbia, MO 65201. E-mail: email@example.com.
This project was supported with faculty research start-up funds by Dr Raymond Foster.
The authors have declared they have no conflicts of interest.