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Lower Urinary Tract Symptoms in Patients With Uterine Fibroids: Association With Fibroid Location and Uterine Volume

Parker-Autry, Candace MD*; Harvie, Heidi MBA, MD†; Arya, Lily A. MD, MS‡; Northington, Gina M. MD, PhD‡

Female Pelvic Medicine & Reconstructive Surgery:
doi: 10.1097/SPV.0b013e31820c99a9
Original Articles
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Objective: To examine the prevalence of lower urinary tract symptoms (LUTS) in women with symptomatic uterine fibroids and investigate their relationship with fibroid location and uterine volume.

Methods: This was a cross-sectional study including 78 women seeking surgical treatment for symptomatic uterine fibroids. The validated Bristol Female Lower Urinary Tract Symptom-Scored Form (BFLUTS-SF) questionnaire was administered before surgical intervention. Uterine volume and BFLUTS-SF subscale scores or symptoms were compared using Student t test. Multivariate models explored the association between dominant fibroid location and BFLUTS-SF subscale scores.

Results: The most prevalent LUTS were nocturia (91%), urgency (59%), and urinary incontinence (45%-54%). Mean uterine volume and length were 672 ± 714 cm3 and 13 ± 4.24 cm, respectively. Women with moderate and severe urinary urgency had significantly larger uterine volumes (P = 0.017). Mean voiding subscale scores were significantly higher in women with dominant anterior fibroids compared with those with non-anterior fibroids (voiding subscale scores, 2.84 ± 3.03 vs 1.30 ± 2.07, respectively; P < 0.01). This remained significant after adjusting for age, parity, body mass index, and imaging modality.

Conclusions: Lower urinary tract symptoms are prevalent in patients with symptomatic uterine fibroids. Further study is needed to determine if surgical therapy improves these LUTSs in this population.

In Brief

Description: Urinary urgency and voiding dysfunction are significantly associated with large fibroid uteri and anterior fibroid location.

Author Information

From the *Division of Women's Pelvic Medicine and Reconstructive Surgery,Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL; †Chestnut Hill Women's Health Associates; and ‡Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania School ofMedicine, Philadelphia, PA.

Reprints: Gina Northington, MD, PhD, Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, The Hospital of the University of Pennsylvania, 3400 Spruce St./1000 Ravdin Courtyard, Philadelphia, PA 19104. E-mail:

© 2011 by Wolters Kluwer Health | Lippincott Williams & Wilkins