The Cancer Journal

Skip Navigation LinksHome > July/August 2012 - Volume 18 - Issue 4 > Genetic Testing by Cancer Site: Uterus
Cancer Journal:
doi: 10.1097/PPO.0b013e3182610cc2
Genetic Testing by Cancer Site

Genetic Testing by Cancer Site: Uterus

Daniels, Molly S. MS, CGC

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Abstract: This review article discusses hereditary cancer predisposition syndromes with uterine manifestations. Lynch syndrome accounts for 2% to 3% of endometrial cancers. The identification of endometrial cancer patients at risk for Lynch syndrome is discussed, as are the characteristics of Lynch syndrome–associated endometrial cancer and the screening and prevention options for women at risk for Lynch syndrome–associated endometrial cancer. Endometrial cancer associated with PTEN hamartoma tumor syndrome (also known as Cowden syndrome) is also discussed. HLRCC (hereditary leiomyomatosis and renal cell carcinoma), which has an associated high risk of symptomatic uterine leiomyomas, is reviewed.

© 2012 Lippincott Williams & Wilkins, Inc.


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