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Cancer Journal:
doi: 10.1097/PPO.0b013e31826246c2
Genetic Testing by Cancer Site

Genetic Testing by Cancer Site: Ovary

Weissman, Scott M. MS, CGC; Weiss, Shelly M. MS, CGC; Newlin, Anna C. MS, CGC

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Abstract: Approximately 1 in every 4 to 5 women with a diagnosis of ovarian cancer has a hereditary gene mutation that is responsible for the development of her cancer. Identifying women at increased risk of developing ovarian cancer due to a hereditary cancer syndrome can allow for early detection or prevention of not only ovarian cancer, but also other cancers, depending on the causative gene. This review focuses on 3 of the most common hereditary ovarian cancer syndromes, hereditary breast and ovarian cancer syndrome (the BRCA1 and BRCA2 genes), Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome), and Peutz-Jeghers syndrome, including key features, genetics, and management of these syndromes. In addition, newly discovered genes (eg, RAD51C and RAD51D) linked to ovarian cancer are discussed.

© 2012 Lippincott Williams & Wilkins, Inc.


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