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The Role of MicroRNAs in Colorectal Cancer

Schetter, Aaron J. PhD, MPH; Okayama, Hirokazu MD; Harris, Curtis C. MD

doi: 10.1097/PPO.0b013e318258b78f
Reviews

Abstract: During the last decade, it has become clear that aberrant microRNA expression has a functional role in the initiation and progression of colorectal cancer (CRC). Specific microRNAs can act as either tumor suppressors or oncogenes depending on the cellular environment in which they are expressed. The expression of microRNAs is reproducibly altered in CRC, and their expression patterns are associated with diagnosis, prognosis, and therapeutic outcome in CRC. Studies have begun to examine the association of microRNA-related polymorphisms and their association with CRC incidence and prognosis as well as the possibility of using circulating microRNAs or fecal microRNA expression as noninvasive early detection biomarkers. These data suggest that microRNAs may be potential molecular classifiers, early detection biomarkers, and therapeutic targets for CRC. Here, we will review the evidence demonstrating a role of microRNAs in CRC.

From the Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Conflicts of Interest and Source of Funding: All authors receive funding from the Intramural Research Program of the National Cancer Institute, National Institutes of Health.

Reprints: Curtis C. Harris, MD, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 3068A, MSC 4258, Bethesda, MD 20892-4258. E-mail: curtis_harris@nih.gov.

© 2012 Lippincott Williams & Wilkins, Inc.