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Journal of Infusion Nursing:
doi: 10.1097/NAN.0000000000000018
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Feasibility of Home Infusion and Self-Administration of Nanofiltered C1 Esterase Inhibitor for Routine Prophylaxis in Patients With Hereditary Angioedema and Characterization of a Training and Support Program

Gregory, Cherylann BSN, RN; Landmesser, Ladonna M. PharmD; Corrigan, Larry MBA, BA; Mariano, David PharmD

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Abstract

Hereditary angioedema (HAE) is a rare, chronic disease of C1 inhibitor deficiency. Study researchers evaluated the prevalence of home and self-administration of nanofiltered, human-derived C1 esterase inhibitor infusions and the implementation of a nursing training and support program. Home administration rate increased from 49.0% to 75.8%. The percentage who self-administered increased from 20.3% to 43.9%. Doses per week averaged 1.85 at home compared with 1.40 in infusion centers and physicians' offices. Patients required an average of 5 visits to be trained. Self-administration is a viable, feasible option in the management of HAE, which is facilitated by a nurse-managed training and support program.

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