Apheresis is an effective desensitization modality for removing antibodies against donor-specific human leukocyte antigens or ABO blood type antigens to facilitate transplantation. Apheresis is also used to treat acute antibody-mediated rejection, in conjunction with immunosuppressive medications, in recurrent focal and segmental glomerulosclerosis and other glomerular diseases, in correction of coagulopathy, in supportive therapy in acute liver failure patients awaiting liver transplant, and in the treatment of drug-induced thrombotic microangiopathy. Transplant recipients who receive apheresis need close monitoring for infections and for potential bleeding complications associated with surgery or biopsy.
University of Wisconsin Madison, WI.
Brenda Muth, MS, RN, ACNP, holds bachelor's and master's degrees in nursing from the University of Wisconsin. A transplant nephrology acute care nurse practitioner, she works with adult kidney and other solid transplant recipients. In addition, she works in the organization's desensitization program.
Corresponding Author: Brenda Muth, MS, RN, ACNP, 1685 Highland Avenue 5143, UW Medical Foundation Centennial Building, Madison, WI 53705.
The author of this article has no conflicts of interest to disclose.