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Analyses Comparing the Antimicrobial Activity and Safety of Current Antiseptic Agents: A Review

Hibbard, John S. PhD

Article

This article reviews the results and conclusions from four pivotal and two comparative clinical trials. The six randomized, controlled, single-blinded, parallel-group clinical trials were conducted to determine which antiseptic is best for use as a patient preoperative skin preparation. The objective of these studies was to compare the immediate, persistent (residual), and cumulative antimicrobial efficacy and safety of 2% chlorhexidine gluconate (CHG) combined with 70% isopropyl alcohol (IPA) (ChloraPrep); another combination CHG and IPA antiseptic (CHG+IPA) and 2% aqueous CHG alone; 4% CHG (Hibiclens) alone; 70% isopropyl alcohol (IPA) alone; and an iodine-containing solution, 10% povidone-iodine (Betadine) alone as preoperative skin topical antiseptics for potential prevention of nosocomial infections.

This article reviews the results and conclusions from four pivotal and two comparative clinical trials. The six randomized, controlled, single-blinded, parallel-group clinical trials were conducted to determine which antiseptic is best for use as a patient preoperative skin preparation. The objective of these studies was to compare the immediate, persistent (residual), and cumulative antimicrobial efficacy and safety of 2% chlorhexidine gluconate (CHG) combined with 70% isopropyl alcohol (IPA) (ChloraPrep); another combination CHG and IPA antiseptic (CHG+IPA) and 2% aqueous CHG alone; 4% CHG (Hibiclens) alone; 70% isopropyl alcohol (IPA) alone; and an iodine-containing solution, 10% povidone-iodine (Betadine) alone as pre-operative skin topical antiseptics for potential prevention of nosocomial infections.

John S. Hibbard is a consultant with 8 years of experience consulting and conducting clinical research trials with antiseptic agents. He also has 15 years of experience conducting clinical research studies for other pharmaceutical drugs and 10 years of experience teaching clinical microbiology to medical students. He has authored and co-authored more than 23 publications and review articles in parasitology, clinical microbiology, and clinical research on oncology and gastrointestinal drugs, antibiotics and antiseptic agents.

Address correspondence to: John S. Hibbard, J & A Companies, LLC, 4311 W. 112th Terrace, Leawood, KS 66211 (email: JSHibbard@aol.com)

© Copyright 2005 by the Infusion Nurses Society