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Determination of Theophylline Clearance After Cimetidine Infusion in Critically Ill Patients

Mojtahedzadeh, Mojtaba PharmD; Sadray, Sima PharmD; Hadjibabaie, Molouk PharmD; Fasihi, Mohiodin MD; Rezaee, Saeed PharmD

Journal of Infusion Nursing:
Articles
Abstract

Abstract: The potential for continuous infusion of cimetidine to affect the clearance of aminophylline was assessed in 18 critically ill patients treated for bronchospasm. This was a pharmacokinetic drug‐drug interaction study in which the subjects were administered aminophylline as a continuous infusion at low doses (mean 10.8 mg/hr). Subjects were started on cimetidine (50 mg/hr) 24 hours post aminophylline drip and remained on it for 48 hours. Theophylline clearance was determined right before and 48 hours after starting cimetidine. There were no significant differences in theophylline clearance before and after infusion of cimetidine (P > .05). Based on our findings, cimetidine does not seem to affect the clearance of low doses of theophylline in critically ill patients.

Author Information

Mojtaba Mojtahedzadeh is Associate Professor in the Department of Pharmacotherapy, School of Pharmacy, Tehran University of Medical Sciences.

Sima Sadray is Assistant Professor in the Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences.

Molouk Hadjibabaie is Assistant Professor in Department of Pharmacotherapy, School of Pharmacy, Tehran University of Medical Sciences.

Mohiodin Fasihi is Assistant Professor in Sina University Hospital, Department of Critical Care Medicine, Tehran University of Medical Sciences.

Saeed Rezaee is Industrial Pharmacy Resident in the Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences.

Address correspondence to: Molouk Hadjibabaie, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155‐6451, Iran (e‐mail: hadjibabaie@hotmail.com).

© Copyright 2003 by the Infusion Nurses Society