The transplantation of hematopoietic stem cells is sometimes the only treatment option for certain types of malignancies and hematological disorders. The best way to ensure a positive outcome from this type of procedure is to secure an identical human lymphocyte antigen-matched donor or use an autologous graft. This article reviews the indications for transplantation, the recipient and donor selection process, and posttransplant follow-up. The advantages of using haploidentical donors and the typing process also will be discussed.
Lorita M. Rebellato is an Assistant Professor of Pathology at Brody School of Medicine, East Carolina University, and the Scientific Director of the Histocompatibility Laboratory at Pitt County Memorial Hospital, Greenville, North Carolina. She has been involved with HLA typing in both the research and clinical setting for many years. She is currently responsible for establishing the protocols and performing the necessary correlation studies to perform HLA Class I and II typing using PCR-based methods at Pitt County Memorial Hospital.
Larry J. Dobbs, Jr, is an Associate Professor of Pathology at Brody School of Medicine, East Carolina University, and is the Medical Director of the DNA Diagnostics Laboratory at Pitt County Memorial Hospital, Greenville, North Carolina. His research interests are in the development of clinical testing using DNA methods with emphasis on diagnosis of hematologic malignancies and the detection of recurrent or minimal residual disease.
Address correspondence to: Lorita M. Rebellato, East Carolina University School of Medicine, Department of Pathology, Brody Building Room 7S-10, Greenville, NC 27858 (e-mail: firstname.lastname@example.org).