Journal of Addiction Medicine

Skip Navigation LinksHome > July/August 2013 - Volume 7 - Issue 4 > The Synthetic Cannabinoid Withdrawal Syndrome
Journal of Addiction Medicine:
doi: 10.1097/ADM.0b013e31828e1881
Case Report

The Synthetic Cannabinoid Withdrawal Syndrome

Nacca, Nicholas MD; Vatti, Deepak BS; Sullivan, Ross MD; Sud, Payal MD; Su, Mark MD; Marraffa, Jeanna PharmD

Collapse Box


Background: Little is known about the effects of synthetic cannabinoids. There has been only one previous report of a withdrawal syndrome from synthetic cannabinoids. We report two cases of a withdrawal syndrome from prolonged habitual use of synthetic cannabinoids.

Discussion: Withdrawal from delta-9-THC has been described as a syndrome of anxiety, myalgias, chills, and anorexia. Synthetic cannabinoids are potent than delta-9-THC and thus the withdrawal syndrome is similar but more severe; however the symptoms do not seem to improve with delta-9-THC. The differences in presentation could be due to the fact that synthetic products may contain several heterogeneous compounds, including amphetamine-like substances.

Conclusions: The acute withdrawal syndrome appears to be characterized mainly by anxiety and tachycardia in the absence of any neurological findings or electrolyte disturbances. We describe two patients with symptoms consistent with withdrawal presumably due to synthetic cannabinoid use. The most appropriate treatment for such patients remains unknown, however benzodiazepines are a reasonable first line approach and quetiapine may have some efficacy.

© 2013 American Society of Addiction Medicine

Follow us on Social Media!



Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.