Obesity and binge eating disorder are detrimental health conditions that are associated with lower qualities of life. Individuals with obesity often face societal discrimination and frequently experience related medical disorders such as diabetes, hypertension, and hyperlipidemia. Current research suggests neurobiological similarities among obesity, binge eating disorder, and substance dependence. In addition, behavioral similarities link the two conditions; obese and substance-dependent individuals often report similar features such as cravings and diminished control over consumption of food and substances, respectively. Treatment options for obesity have begun to use this information to formulate pharmacological and therapeutic interventions that may provide improved results for weight loss and decreased binge frequency. Similarly, treatment approaches to substance addictions should consider aspects of weight management. Findings from research and treatment studies are presented with the aim of reviewing the current literature of obesity within the context of an addiction framework and providing information on empirically supported approaches to the treatment of co-occurring obesity and substance addiction.