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Journal of Addiction Medicine:
doi: 10.1097/ADM.0b013e31806c9202
Invited Review

Buprenorphine: The Basic Pharmacology Revisited

Cowan, Alan PhD

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Abstract

The historical background leading to the current use of buprenorphine as an analgesic and its role in the management of opioid dependence is summarized. The popular description of buprenorphine as a “partial agonist” is discussed in relation to efficacy in animal models of antinociception and clinical analgesia. The latest information on the respiratory depressant effects of buprenorphine and its N-dealkylated metabolite (norbuprenorphine) is presented. New data on the buprenorphine withdrawal syndrome in rats are described.

© 2007 American Society of Addiction Medicine

    

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