Background: Tranexamic acid (TXA) is an anti-fibrinolytic drug that has been shown to be effective in reducing blood loss and the need for transfusions after several orthopedic surgeries. However, the effectiveness of TXA use in orthopedic fracture surgeries still remains unclear. The purpose of this meta-analysis was to review existing literature with interest in the effectiveness and safety of TXA treatment in reducing total blood loss and transfusion rates for patients who underwent surgery for fracture repairs.
Methods: An electronic literature search of PubMed, Embase, OVID, and the Cochrane Library was conducted to identify studies published before December 2016. All randomized controlled trials and cohort studies evaluating the efficacy of TXA during fracture repair surgeries were identified. Primary outcome measures included the number of patients receiving a blood transfusion and peri-operative total blood loss. Data were analyzed using Comprehensive Meta Analysis (CMA) statistical software.
Results: Seven studies encompassing 559 patients met the inclusion criteria for the meta-analysis. Our meta-analysis indicated that when compared with the placebo control group, the use of TXA in fracture surgeries significantly reduced total blood loss by approximately 330 mL (p=0.009), reduced the transfusion rate with a relative risk of 0.54 (p<0.001), and decreased the drop of hemoglobin by 0.76 g/dL (p<0.001). There was no significant difference between the number of thrombo-embolic events among the study groups (p=0.24).
Conclusions: This study demonstrated that tranexamic acid may be used in orthopedic fracture surgeries to reduce total blood loss, transfusion rates, and the drop in hemoglobin level, without increasing risk of venous thrombo-embolism. A limitation to these findings is the small number of studies available. Further studies need to be conducted to confirm these findings.
Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.e
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