In 1913, Karl Jaspers, a 30-year-old psychiatrist at Heidelberg University, published the first edition of a book called General Psychopathology (Jaspers, 1913a). For the current reader to understand the remarkable accomplishment of Jaspers and his powerful mind, he/she would need to ask a current psychiatry resident to write a book summarizing psychiatric knowledge, including the methodological and scientific aspects of psychiatry (Berrios, 2013). Labeling Jaspers a resident is obviously not historically correct because there were no psychiatry residents at that time, but it is not far from the truth because he was a psychiatry trainee. In 1906, Jaspers was a medical student. He moved to Heidelberg after his physician recommended it. Jaspers had been diagnosed with bronchiectasis at a time when antibiotics were not available; thus, he was not expected to live much longer than his early 30s. His physician recommended “a rigid and restricted working routine that was intended to prolong his life” (Kirkbright, 2004). In 1908, after his medical licensing examination, Jaspers took an unpaid job as a trainee in the outpatient clinic. There, he worked with the psychiatry chairman Franz Nissl (a world-renowned neuropathologist who had been the chairman since 1904 when Kraepelin moved to Munich) on his dissertation in forensic psychiatry, which led to Jaspers’ formal appointment in July 1909 (Janzarik, 1998). At that time, the clinic at Heidelberg was an exciting place with many brilliant psychiatrists, including William Mayer-Gross. Jaspers was fortunate to have the support of his wealthy family and was released from clinical duties but had free access to patients, the library, and scientific discussions. During 1911 and 1912, Jaspers developed the ideas and themes that led to General Psychopathology (Janzarik, 1998). An article comparison between delusions in schizophrenia and jealousy (Jaspers, 1913b, 2007) led to the key concepts of explaining and understanding, which were incorporated in General Psychopathology. In this book, Jaspers combined the clinical information known at that time with his personal ideas derived from some philosophical thinkers (mainly Kant and Dilthey; Berrios, 2013).
Jaspers thought that the discipline of psychiatry “was crying out for a systematic clarification of current thinking” (Kirkbright, 2004). He used General Psychopathology as a professorial thesis in psychology, thus allowing him to migrate toward teaching psychology. Later, he became a professor and an internationally known philosopher and abandoned psychiatric practice completely (Kirkbright, 2004). As a matter of fact, in 1916, a chairman was needed at Heidelberg and Jaspers was asked; he declined because he thought he might not be able to handle the physical exertion (Janzarik, 1998).
In 1921, a young psychiatrist, Kurt Schneider, who was working on his philosophical dissertation, wrote to Jaspers, asking his permission to dedicate his dissertation to him. In 1922, Jaspers was no longer in direct contact with psychiatry and was writing the third edition of his book; in the process, he wrote to Schneider, asking for suggestions (Janzarik, 1998). According to Berrios (2007), starting with the fifth edition of General Psychopathology, all updates were done by Schneider because Jaspers had not seen patients for 30 years. Schneider wrote a short textbook called Clinical Psychopathology, which was translated into English in 1959 (Schneider, 1959). This is a short summary for the clinicians who could not easily understand the “too philosophical” and lengthy General Psychopathology. Schneider’s life trajectory was the opposite of that of Jaspers; his contact with philosophy was soon after finishing his medical education, but he became a practicing psychiatrist and an excellent clinician. Schneider was probably one of the top German psychiatric clinicians in 1931, he was hired as the director of the Clinical Department of the German Institute for Psychiatric Research (Hoenig, 1982; Huber, 1987). Kraepelin (1920a) opened this Research Institute in 1917 to use the neurosciences “to make clear the nature and the sources of mental disturbances, and then to discover ways of preventing them, healing them or making them easier to bear.” Schneider’s and Jaspers’ opposite life trajectories converge at two important points. Like Jaspers, Schneider a) did not want to cooperate with the Nazi university and b) was recruited by the US government to resuscitate Heidelberg University after it was reopened in 1945, once the Second World War ended. Schneider taught psychiatry and Jaspers taught philosophy (Hoenig, 1982; Huber, 1987; Kirkbright, 2004).
The Great Influence of General Psychopathology in the United Kingdom
The first English translation of General Psychopathology included more than 900 pages and was published in 1963, reflecting the 1942 German edition, which was the seventh and final edition (Jaspers, 1963). The translation was made by the psychiatrist Julius (John) Hoenig (who was born in Prague, Czechoslovakia, but left after Hitler invaded it; BMJ Obituaries, 2009) and Marian W. Hamilton (a social worker), with experience in translating German psychiatric books, including Schneider’s Clinical Psychopathology. In 1947, when Hoenig was teaching psychiatry residents at the Institute of Psychiatry (IOP) in London, Aubrey Lewis (the chairman) recommended Jaspers’ book to Hoenig (2004). In 1949, Hoenig (2004) decided to translate General Psychopathology when he moved to Manchester, where Clinical Psychopathology was used to teach psychiatry residents and where Ms Hamilton was working. The translation of General Psychopathology was one of the multiple steps in the complex transference of knowledge and ideas from Heidelberg to the United Kingdom (Table 1). Academic psychiatrists trained in Germany and Central Europe, exposed to a scientific approach and heavily influenced by Kraepelin and Jaspers, became key influences on British psychiatry after migrating to the United Kingdom (Peters, 1996). The contribution of Mayer-Gross (Lewis, 1977), who trained in Heidelberg and moved to the United Kingdom (Table 1), was crucial because the three editions of his textbook Clinical Psychopathology (Mayer-Gross et al., 1954, 1960; Slater and Roth, 1977) trained psychiatrists in the United Kingdom before the publication of the Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III). Mayer-Gross’ influence in the IOP was crucial in the use of a narrow concept of schizophrenia influenced by Jaspers and Schneider in the United Kingdom (Bourdillon et al., 1965; Wing, 1983; Wing et al., 1967, 1974). Mayer-Gross trained Martin Roth, who became chairman of psychiatry at the University of Cambridge and brought German E. Berrios to Cambridge. Berrios collaborated with the University of Heidelberg and developed his interest in epistemology at the University of Cambridge (Fuentenebro de Diego et al., 2000). As Table 1 demonstrates, Jaspers has had a continuous influence on British psychiatry, including psychiatric research (Wing, 1983) and the training of the residents (Goldberg, 2013; Harrison, 1991; Shepherd, 1982).
The Limited Influence of General Psychopathology in the United States
Whereas the emigrating psychiatrists fleeing from the Nazis brought Jaspers’ and Schneider’s ideas to the United Kingdom, the emigration of German and Centro-European psychiatrists to the United States brought psychoanalysts to the United States. By the mid-1950s, nearly every department chairman of psychiatry in the United States was an advocate of psychoanalysis (Decker, 2007; Kendler et al., 2010; Wilson, 1983). This changed upon the advent of the neo-Kraepelinian revolution, which started at Washington University in St Louis (Blashfield, 1982; Decker, 2007; Kendler et al., 2010; Table 2).
Kraepelin’s nosology was developed by focusing on course and outcome as a critical defining feature of psychiatric illness, as was done in medical disorders (Weber and Engstrom, 1997). In General Psychopathology, Jaspers criticized Kraepelin because not all psychiatric disorders followed the medical model. In 1970, Robins and Guze discussed diagnostic validity in psychiatry, focusing on schizophrenia. They proposed five steps: a) clinical description, b) laboratory studies, c) delimitation from other disorders, d) follow-up study, and e) family study. This model was used in establishing validity in all psychiatric disorders. Robins and Guze (1970) did not quote Kraepelin in their article, but their approach is essentially Kraepelinian, and this is why these authors have been called neo-Kraepelinian (Decker, 2007; Klerman, 1978).
The differences in timing and in the level of Jaspers’ influence on British and US psychiatry and on the diagnosis of schizophrenia are obvious when one compares Table 1 with Table 2. Table 2 describes the chronology of the neo-Kraepelinian movement in the United States, which developed with very limited attention to Jaspers.
General Psychopathology is rarely read by US psychiatrists and probably has had very limited direct impact on US psychiatry. Hoenig (2004) described a visit to a psychiatry chairman at a medical school in Philadelphia. The chairman told him, “Nobody reads it, but it is obligatory to have it seen on your shelf.” The American Journal of Psychiatry has published only two articles focused on Jaspers. In 1967, Havens commented on the publication of the English translation of General Psychopathology and hoped that US psychiatrists would be open to Jaspers, who “provides a systematic rationale for eclecticism” (Havens, 1967), but his hopes did not become a reality. In 1993, Mundt, a German author, published a short biography of Jaspers in the section Images in Psychiatry of the American Journal of Psychiatry (Mundt, 1993). A third article comments on Jaspers’ concepts of explaining and understanding in the context of Engel’s biopsychosocial model (Schwartz and Wiggins, 1986). The Journal of Nervous and Mental Disease has published only one article on Jaspers, in which Havens (1972) focused on existential psychiatry [Editor’s Note: A review of Jasper’s book, Nietzsche Einfuhrung in Das Verstandnis Seines Philosophierens, appeared in this Journal in November 1938, accessible at http://journals.lww.com/jonmd/Citation/1938/11000/Nietzsche_Einfuhrung_in_Das_Verstandnis_Seines.67.aspx]. This is in contrast (Table 1) to the British Journal of Psychiatry, which has published three book reviews of General Psychopathology (Harrison, 1991; Shepherd, 1982; Trethowan, 1963), three reflections on the centennial anniversary of General Psychopathology (Berrios, 2013; Goldberg, 2013; Sims, 2013), one article by Jaspers (1968), and one article focused on Jaspers’ concepts of explaining and understanding (Ebmeier, 1987).
Ignoring General Psychopathology Led to a Broad Concept of Schizophrenia in the United States
The lack of interest of US psychiatry in General Psychopathology led to a view of schizophrenia diagnosis mainly influenced by Bleuler and psychoanalysis, and this, not surprisingly, led to a broad set of criteria for diagnosing schizophrenia, much broader than the British criteria. The words “not surprisingly” are a reference to the obvious differences between Kraepelin’s and Bleuler’s theories about schizophrenia (Bleuler, 1950; Hoenig, 1995; Kraepelin, 1920b, 1992; McNally, 2009), which were apparent from the beginning (first panel of Table 3). This difference in their concepts of schizophrenia led, in the 1920s, to the first schizophrenia rift (Hoenig, 1983); this first rift was between German-speaking psychiatrists (second panel of Table 3). German psychiatrists following Kraepelin and Jaspers and led by Mayer-Gross argued with Swiss psychiatrists following Bleuler, who was influenced by psychoanalysis through Carl Jung (first panel of Table 3). This clash between German and Swiss psychiatrists about what constituted schizophrenia probably influenced Schneider, who developed his first-rank symptoms for the purpose of diagnosing schizophrenia in a more reliable way (third panel of Table 3). In the 1940s, there was an obvious convergence in the concepts of schizophrenia between the Swiss and the Germans, manifested by the coming together on this issue of Bleuler’s son (Bleuler, 1978) and Schneider’s main disciple (Huber et al., 1980; fourth panel of Table 3).
The second schizophrenia rift was between English-speaking psychiatrists, US and British psychiatry. Because this dispute is one of the key historical elements that led to the development of the DSM-III in the United States (Table 2), it deserves some specific attention (Feighner et al., 1972; Robins and Guze, 1970; Rosenhan, 1973; Spitzer et al., 1978a, 1978b). In the 1960s, it became obvious that British hospitals had a narrower conception of schizophrenia and US hospitals tended to diagnose manic-depressive illness less (Kramer, 1969). This led to the collaboration (Zubin, 1969) of the London IOP and the New York State Psychiatric Institute (NYSPI). The IOP was heavily influenced by Jaspers’ and Schneider’s ideas (Wing, 1983) when it was developing a psychiatric diagnostic interview for research (Table 1). The NYSPI was a crucial element in the US neo-Kraepelinian revolution because Robert Spitzer was working there to develop ways to standardize psychiatric diagnoses. In 1970, Gurland et al. published the largest clinical sample of the US-UK study comparing psychiatric diagnoses in a random sample of patients admitted to these two hospitals (Gurland et al., 1970). The prevalence of schizophrenia diagnosis was 56% in New York versus 48% in London. A continuation study used eight psychiatric patient tapes (Kendell et al., 1971). Five of the eight tapes were rated by 30 to 40 British psychiatrists from the IOP; and three, by 200 all over the country. In the United States, two tapes were rated by 120 psychiatrists; and six, by 30 to 60 US psychiatrists, but most of them were from New York. It was obvious that the US psychiatrists tended to have a broader definition of schizophrenia. The authors stated, “Probably the most important cause of the Anglo-American discrepancies revealed here is that the American concept of schizophrenia has expanded greatly in the last 30 years without any corresponding enlargement of the British concept. The reasons for this divergence are complex, but the greater influence of the psychoanalytic movement in North America and influential teachers on both sides of the Atlantic, have been more important than any factual discoveries” (Kendell et al., 1971).
Later on, it was clear that these differences between the IOP and the NYSPI were the tip of the iceberg and that, before the DSM-III, the diagnostic criteria set for schizophrenia in the United States was much broader than in the United Kingdom. The publication of the Vermont longitudinal study of institutionalized patients demonstrated that only 56% (149/268) of the patients originally diagnosed with DSM-I schizophrenia met DSM-III schizophrenia criteria (Harding et al., 1987). The 44% of DSM-I–diagnosed schizophrenia patients who had different diagnoses according to DSM-III included 17% (44/268) with affective disorders, 7% (18/268) with atypical psychoses, 8% (22/268) with organic mental disorders, and 12% (32/268) with other diagnoses (Harding et al., 1987). In summary, according to US psychiatrists trained in psychoanalytic theory before the 1980s, almost any patient who had psychosis or severe mental illness had schizophrenia, and a good number (almost half in the Vermont sample) of these patients with DSM-I schizophrenia would be diagnosed instead with other disorders by using traditional German and post–DSM-III US definitions of schizophrenia.
The Undeniable Complexity of General Psychopathology
Despite the repeated recommendations over time by British psychiatrists (Goldberg, 2013; Harrison, 1991; Shepherd, 1982) that psychiatry residents should read General Psychopathology, the author’s experience is that current US psychiatry residents, who usually lack any philosophical training, cannot understand selected chapters from this book unless they are intensively coached and helped. The literature provides ample evidence of the complexity of reading General Psychopathology. Hoenig (2004) reported that three German professors of psychiatry thanked him for the English translation, but facetiously commented that they had never been able to read the book in German, and were now glad to be able to read the book in English. The complexity of Jaspers’ writing almost had lethal consequences for Jaspers. Jaspers’ wife was Jewish and was on the list to be taken to the concentration camps. Jaspers tried to immigrate to the United States by seeking employment at Princeton University (Oliver, 1988). Unfortunately, Albert Einstein did not recommend him, saying that Jaspers’ writings “affected him like the talk of an intoxicated person” (Oliver, 1988) and comparing him to one of the most obscure German philosophers (Hegel). In March 1945, Jaspers heard that he and his wife were to be deported to a concentration camp on April 14 of that year; fortunately, the US troops occupied Heidelberg on April 1 (Hoenig, 1966).
General Psychopathology contains two absolutely essential interrelated ideas concerning the practice of psychiatry (de Leon, 2013): a) psychiatry is a hybrid scientific discipline that must combine the methods of the natural and the social sciences that provide an explanation of illness that follows the medical model and an understanding of psychiatric abnormalities that are variations of human living, respectively, and, therefore, b) psychiatric disorders are heterogeneous (some are medical illnesses; some are variations of normality; and others are in the middle, such as schizophrenia and severe mood disorders).
Although this article proposes that General Psychopathology has had limited influence in the United States, it has had an important influence on Paul McHugh, who, after his psychiatry residency at Harvard, trained for 1 year at the IOP. McHugh was chairman and professor of psychiatry at Johns Hopkins University for approximately 25 years starting in 1975. Nancy Andreasen wrote an article stating that an “unintended consequence of the DSM-III was the ‘death’ of the recently resurrected US interest in Jaspers’s writing” (Andreasen, 2007). The author thinks that it is a superb article, but he has a minor disagreement. Andreasen reported, “However, a few American institutions maintained ties with Anglo-European psychiatry. The institutions have sometimes been called ‘the Mid-Atlantics.’ They included Washington University in St Louis, Johns Hopkins in Baltimore, Iowa Psychiatric Hospital in Iowa City, and New York Psychiatric Institute in New York City.” Then, she was to explain that these institutions led what other authors have called the neo-Kraepelinian revolution. Although no one would disagree with considering Washington University, Iowa Psychiatric Hospital in Iowa City, and the NYSPI the core of the neo-Kraepelinian revolution (Blashfield, 1982), it seems to the author that it is better to come out with a “neologism” to label McHugh’s approach as neo-Jasperian rather than neo-Kraepelinian.
McHugh provided very clear summaries of Jaspers’ fundamental ideas. The author uses McHugh’s textbooks (McHugh and Slavney, 1982; Slavney and McHugh, 1987) to teach US psychiatry residents, many of whom are foreign medical graduates, who have difficulties understanding General Psychopathology and are not willing to read more than a few pages even with considerable coaching by the author. A crucial point in Jaspers’ General Psychopathology is the distinction between “Erklären,” which usually gets translated as “explaining” or “providing casual explanations,” and “Verstehen,” which usually gets translated as “understanding” or “providing meaningful understanding.” McHugh and Slavney (1982) describe explaining. “According to Jaspers, this explaining `from the outside’ is inescapable because causal connections have their foundations in the somatic realm, in biological phenomena that are themselves beyond the reach of consciousness and thus beyond the reach of understanding. In his view, causal connections can be established only empirically, by the hypothetico-deductive methods of the natural sciences” (pp. 34–35). They describe “understanding” as follows: “By contrast … methodologists of the social sciences argued that human activity could not be understood in such a manner, that distinctively human actions were not lawlike or causal in the specific sense in which these terms and their cognates applied to physical nature. Rather, human phenomena generally could be understood properly only in terms of what it is that agents of such actions themselves believed that they were doing or intended to do. Thus … to understand a human action requires that one understand the way or ways in which the agent of the action himself understands and interprets his own action; its ‘meaning’ is the meaning it has for the agent whose action it is. Beliefs and intentions, unlike natural phenomena, connote the conscious activity of agents subject to their own free (or relatively free) choice, or at least to their own self-comprehension” (pp 35–36).
The next sections describe two neo-Jasperian approaches from the late 20th century, Berrios’ ideas on the hybridity of psychiatry in the United Kingdom and McHugh’s ideas on psychiatric diagnoses in the United States. Because of limited space, this article does not review the work of S. Nassir Ghaemi, another important neo-Jasperian in the United States. Ghaemi’s most important contribution is his book The Concepts of Psychiatry (Ghaemi, 2007a), which is heavily influenced by Jaspers. He has also written articles on the contributions of Jaspers to the scientific approach in psychiatry (Ghaemi, 2007b, 2007c, 2008) and on the excessive number of psychiatric diagnoses in the DSM versions after DSM-III (Ghaemi, 2009).
The Hybridity of Psychiatry: Jaspers’ Influences on Berrios
Berrios is the retired chairman of epistemology and psychiatry at the Department of Psychiatry of the University of Cambridge in the United Kingdom. As Table 1 shows, he is the last link in the chain transmitting Jaspers’ ideas to the United Kingdom. As a neo-Jasperian, Berrios reminds us again at the beginning of the 21st century of the unfortunate methodological position of psychiatry: dealing with hybrid objects with different levels of difficulty of study using the traditional scientific methods practiced in medicine. Using his words, “Psychiatry can be defined as a theoretical and practical discipline whose epistemological structure straddles the natural and human sciences” (Berríos, 2011). Then, he provides a short history of psychiatry for the reader “to understand” (in the Jasperian sense) this hybridity. For this “thorny” issue, “the only solution is to develop a model of mental symptom-formation that blends the biological and semantic components” (Berríos, 2011). He proposes that there may be at least four pathways for symptom formation in psychiatry, described in Table 4 (Berrios and Marková, 2006). Some may be good subjects for a neurosciences approach, but others are not. As did Jaspers and McHugh, Berrios questions whether a “neuroscience” approach is wise for all aspects of psychiatry. When the psychiatric symptoms are closely related to the brain signals, as are those in patients with “neurological” disorders, a neuroscience approach and methods such as brain imaging make sense because these symptoms can be explained by a brain disorder. When the psychiatric symptoms and disorders are related to semantics (interacting human beings), a natural science approach using methods such as brain imaging makes no sense. The symptoms can be understood only in the Jasperian sense and not explained by brain disturbances. These relatively simple concepts imply a level of complexity that may be bad news for current psychiatric researchers. The author wonders if this is why contemporary US psychiatrists tend to neglect Jaspers’ General Psychopathology and the neo-Jasperian approaches of McHugh and Berrios. McHugh’s approaches are reviewed briefly after a brief summary of current status of US psychiatry.
Current US Psychiatry: An Extreme Biological View and a Denial of the Heterogeneity of Psychiatric Disorders
The DSM-III (American Psychiatric Association, 1980) was developed with the intention that it would be “atheoretical,” which is obviously not possible because psychiatric concepts cannot be described independently of the systems used to articulate them (Berrios, 1994). There is general agreement in the literature (Berrios and Marková, 2002; Ghaemi, 2009; McHugh, 2012) that DSM-III and later editions imply but do not specifically describe that all mental disorders are biological brain disorders following the medical model; this has led to the widespread use of psychotropic drugs in the US population.
On the other hand, the leaders of the NIMH, as leaders of psychiatric research in the United States, clearly state that mental disorders are biological brain disorders. Hyman (2007), the prior NIMH director, explained, “Mental disorders are a diverse group of brain disorders that primarily affect emotion, higher cognition and executive function. The boundary between mental and neurological disorders is arbitrary.” One thinks that this view that all mental disorders are brain disorders should be more clearly stated in the Research Domain Criteria (RDoC; Insel et al., 2010), which were developed by the NIMH “to create a framework for research on pathophysiology,” but, unfortunately, this is not clearly articulated. The RDoC ignore mental disorders that do not fit the concept of a brain disorder. It is not clear whether the RDoC developers think that such mental disorders do not exist and all mental disorders are brain disorders, as Hyman stated, or whether some mental disorders that cannot be classified as mental disorders should be of concern for psychiatrists but not for psychiatric researchers.
The DSM-5 does not comment on whether all mental disorders can be considered heterogeneous disorders. In the opinion of the author, the DSM-5 seems to take one step backward and another forward. The DSM-III used a multiaxial classification system (American Psychiatric Association, 1980) and, more importantly, recommended listing “personality disorders” and “specific developmental disorders” on axis II. Nobody would deny that the DSM-III was indirectly implying that these are somewhat different types of mental disorders from those listed on axis I. However, the DSM-5 has eliminated the axes (American Psychiatric Association, 2013); therefore, personality disorders seem to be in the same category as the previous axis I diagnoses. This is the step backward, eliminating the limited indication that mental disorders are heterogeneous. The step forward is that DSM-5 provides an “alternative” classification of personality disorder pathology in its Section III, which uses personality traits and follows a “dimensional” perspective.
The Heterogeneity of Psychiatric Disorders: Jaspers’ Influences on McHugh
McHugh (1987) proposed that psychiatrists use four perspectives: a) disease, b) behavior, c) dimensional, and d) self and life story. This approach is described in detail in his excellent textbook Perspectives in Psychiatry; the second edition was published in 1998 (McHugh and Slavney, 1998). In 2005, McHugh wrote a groundbreaking critique of the classification proposed by DSM-III and later editions; it was published in the Journal of the American Medical Association (McHugh, 2005) but has been ignored by US psychiatry. McHugh insisted that, as Jaspers described, psychiatric disorders are heterogeneous entities. Using his words, “The first cluster comprises patients with brain diseases that directly disrupt the neural underpinnings of psychological faculties, such as cognition, emotion, and perception. This family includes those patients with Alzheimer disease, schizophrenia, and bipolar disorder––patients who ‘have’ (or are proposed to ‘have’) structural or functional pathology affecting their brains and thus disrupting particular psychological faculties.” The psychiatric disorders grouped in the other three clusters are not really “diseases” and include patients “vulnerable to mental unrest because of their psychological makeup,” “who adopt a behavior that has become a relatively fixed and warped way of life (i.e., patients with alcoholism, drug addiction, sexual paraphilias, or anorexia nervosa),” and “with distressing mental conditions provoked by events thwarting or endangering their hopes, commitments and aspirations. For example, they experience grief, situational anxiety, homesickness, jealousy, or posttraumatic stress disorder.” In a more recent chapter, McHugh (2012) has further elaborated his ideas, writing, “We proposed four distinct ‘Perspectives’: the Disease Perspective (what a patient ‘has’), the Dimensional Perspective (what a patient ‘is’), the Behavior Perspective (what a patient ‘does’) and the Life Story Perspective (what a patient ‘encountered’).”
The DSM-III and later editions mandate a system developed by “diagnostic democracy,” creating diagnoses through negotiated agreement among experts (Dean, 2012). As McHugh and Slavney (1998) describe in their textbook, a summary of which is found in Table 5, DSM-III and later psychiatric diagnoses are built as disjunctive categories, making them particularly prone to arbitrariness when experts are trying to obtain agreement in defining them. The need to satisfy the interests of different experts when negotiating disjunctive categories is a recipe for multiplying arbitrary diagnostic categories with arbitrary diagnostic criteria. In that context, it is not surprising that McHugh’s recommendations that not all psychiatric disorders can be considered “brain diseases,” which follow the medical model, were ignored. Which expert would like to have his/her favorite disorder downgraded to something other than a “brain disorder”?
In 1913, Jaspers, a 30-year-old German psychiatrist working at the University of Heidelberg, published the first edition of a book called General Psychopathology. The first English translation of General Psychopathology, which reflected the seventh German edition (Jaspers, 1963), was published in the United Kingdom in 1963 and was one of the most important steps in the complex transference of knowledge and ideas from Heidelberg to the United Kingdom and the development of a relatively narrow set of criteria for diagnosing schizophrenia following the German tradition of Kraepelin, Jaspers, and Schneider. Whereas the emigrating psychiatrists fleeing from the Nazis brought Jaspers’ and Schneider’s ideas to the United Kingdom, the emigration of German and Centro-European psychiatrists to the United States brought psychoanalysts to the United States and led to the limited direct impact of General Psychopathology on US psychiatry. US psychiatry’s lack of interest in General Psychopathology led to a conceptualization of schizophrenia that was largely influenced by Bleuler and psychoanalysis. The result was a relatively broad set of criteria for diagnosing schizophrenia when compared with the British diagnosis, constituting a repetition of the scenario described earlier of the German-speaking countries in the 1920s. Almost half of the US patients diagnosed with schizophrenia in the United States before DSM-III would be diagnosed instead with other disorders when the traditional German and post–DSM-III US definitions of schizophrenia were used. The realization that US psychiatrists used a much broader concept of schizophrenia in the 1970s during a set of US-UK studies was one of the key historical elements that led to the development of the DSM-III in the United States in what has been called the neo-Kraepelinian revolution.
Unless readers have some philosophical training, General Psychopathology is a complex book. General Psychopathology contains two absolutely essential interrelated ideas concerning the practice of psychiatry (de Leon, 2013): a) psychiatric disorders are heterogeneous (some are medical illnesses; some are variations of normality; and others are in the middle, such as schizophrenia and severe mood disorders) and, therefore, b) psychiatry is a hybrid scientific discipline that must combine the methods of the natural and the social sciences that provide an explanation of illness that follows the medical model and an understanding of psychiatric abnormalities that are variations of human living, respectively.
Berrios’ ideas on the hybridity of psychiatry in the United Kingdom and McHugh’s ideas on psychiatric diagnoses in the United States, both from the late 20th century, can be considered neo-Jasperian approaches because they remind us of key concepts described in Jaspers’ General Psychopathology.
Berrios reminds us again at the beginning of the 21st century of the unfortunate methodological position of psychiatry: dealing with hybrid objects. Some psychiatric symptoms and some psychiatric disorders are related to semantic components (interacting human beings), for which a natural science approach makes no sense.
McHugh proposed that psychiatrists use four perspectives: a) disease, b) behavior, c) dimensional, and d) self and life story (McHugh, 1987). This system of classifying psychiatric disorders could promote the neo-Jasperian revolution that US psychiatry needs.
The author thanks Lorraine Maw, MA, for editorial assistance and the editor and reviewers who provided excellent suggestions for improving the article.
No commercial organizations had any role in the writing of this article for publication. The author declares no financial relationship with commercial interests in the last 36 months.
The author does not read German; during more than 25 years, he has thoroughly searched for and read English and/or Spanish translations of the important classical German texts described in the article.
American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders (DSM-III) (3rd ed)
. Washington, DC: American Psychiatric Association.
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5) (5th ed)
. Washington, DC: American Psychiatric Publishing.
Andreasen NC (2007) DSM
and the death of phenomenology in America: An example of unintended consequences. Schizophr Bull
. 33: 108–112.
Berrios G (2007) Psicopatología: Pasado, presente y futuro. Informaciones Psiquiátricas
. 189: 2–10.
Berrios GE (1994) Historiography of mental symptoms and diseases. Hist Psychiatry
. 5: 175–190.
Berríos GE (2011) Psychiatry and its objects. Rev Psiquiatr Salud Ment
. 4: 179–182.
Berrios GE (2013) Jaspers and the first edition of Allegmeine Psychopathologie. Br J Psychiatry
. 202: 433.
Berrios GE, Marková IS (2002) Conceptual issues. In D’haenen H, den Boer JA, Willner P (Eds), Biological psychiatry
(pp 1–24). Chichester, England: John Wiley & Sons Ltd.
Berrios GE, Marková IS (2006) Symptoms—Historical perspective and effect on diagnosis. In Blumenfield M, Strain JJ (Eds), Psychosomatic medicine
(pp 27–38). Philadelphia: Lippincott Williams & Wilkins.
Blashfield RK (1982) Feighner et al., invisible colleges, and the Matthew effect. Schizophr Bull
. 8: 1–12.
Bleuler E (1950) Dementia praecox or the group of schizophrenias
. New York: International University Press.
Bleuler M (1978) The schizophrenic disorders: Long-term patient and family studies
. New Haven, CT: Yale University Press.
BMJ Obituaries (2009) Julius Hoenig. BMJ
. 339: 696.
Bourdillon RE, Clarke CA, Ridges AP, Sheppard PM, Harper P, Leslie SA (1965) ‘Pink spot’ in the urine of schizophrenics. Nature
. 208: 453–455.
de Leon J (2013) Is psychiatry scientific? A letter to a 21st century psychiatry resident. Psychiatry Investig
. 10: 205–217.
Dean CE (2012) The death of specificity in psychiatry: Cheers or tears? Perspect Biol Med
. 55: 443–460.
Decker HS (2007) How Kraepelinian was Kraepelin? How Kraepelinian are the neo-Kraepelinians?—From Emil Kraepelin to DSM-III
. Hist Psychiatry
. 18: 337–360.
Ebmeier KP (1987) Explaining and understanding in psychopathology. Br J Psychiatry
. 151: 800–804.
Feighner JP, Robins E, Guze SB, Woodruff RA Jr, Winokur G, Munoz R (1972) Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry
. 26: 57–63.
Fuentenebro de Diego F, Olmo F, Eckart WV, Berrios GE (2000) Heidelberg and Cambridge: History of two university departments [in Spanish]. Rev Asoc Esp Neuropsiquiatr
. 20: 319–330.
Ghaemi SN (2007a) The concepts of psychiatry
. Baltimore: Johns Hopkins University Press.
Ghaemi SN (2007b) Existence and pluralism: The rediscovery of Karl Jaspers. Psychopathology
. 40: 75–82.
Ghaemi SN (2007c) Pluralism in psychiatry: Karl Jaspers on science. Philos Psychiatry Psychol
. 14: 37–66.
Ghaemi SN (2008) On the nature of mental disease: The psychiatric humanism of Karl Jaspers. Existenz
. 3: 1–9.
Ghaemi SN (2009) Nosologomania: DSM
& Karl Jaspers’ critique of Kraepelin. Philos Ethics Humanit Med
. 4: 10. doi:10.1186/1747-5341-4-10.
Goldberg D (2013) Karl Jaspers, general psychopathology. Br J Psychiatry
. 202: 83.
Gurland BJ, Fleiss JL, Cooper JE, Sharpe L, Kendell RE, Roberts P (1970) Cross-national study of diagnosis of mental disorders: Hospital diagnoses and hospital patients in New York and London. Compr Psychiatry
. 11: 18–25.
Harding CM, Brooks GW, Ashikaga T, Strauss JS, Breier A (1987) The Vermont longitudinal study of persons with severe mental illness, II: Long-term outcome of subjects who retrospectively met DSM-III
criteria for schizophrenia. Am J Psychiatry
. 144: 727–735.
Harrison PJ (1991) General psychopathology: Karl Jaspers. A trainee’s view. Br J Psychiatry
. 159: 300–302.
Havens LL (1967) Karl Jaspers and American psychiatry. Am J Psychiatry
. 124: 66–70.
Havens LL (1972) The development of existential psychiatry (Karl Jaspers, E.Minkowski, and Otto Binswanger). J Nerv Ment Dis
. 154: 309–331.
Hoenig J (1966) Karl Jaspers. Int J Neuropsychiatry
. 2: 351–353.
Hoenig J (1982) Kurt Schneider and Anglophone psychiatry. Compr Psychiatry
. 23: 391–400.
Hoenig J (1983) The concept of schizophrenia: Kraepelin-Bleuler-Schneider. Br J Psychiatry
. 142: 547–556.
Hoenig J (1995) Chapter 13. Schizophrenia. Clinical section. In Berrios G, Porter R (Eds), A history of clinical psychiatry
(pp 336–348). London, England: The Athlone Press.
Hoenig J (2004) Karl Jaspers’ General Psychopathology
: The history of the English translation. Hist Psychiatry
. 15: 233–236.
Huber G (1987) Kurt Schneider: The man and his scientific work. Zentralbl Neurol Psychiatr
. 246: 177–191.
Huber G, Gross G, Schüttler R, Linz M (1980) Longitudinal studies of schizophrenic patients. Schizophr Bull
. 6: 592–605.
Hyman SE (2007) Can neuroscience be integrated into the DSM-V
? Nat Rev Neurosci
. 8: 725–732.
Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P (2010) Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. Am J Psychiatry
. 167: 748–751.
Janzarik W (1998) Jaspers, Kurt Schneider and the Heidelberg school of psychiatry. Hist Psychiatry
. 9: 241–252.
Jaspers K (1913a) Allgemeine psychopathologie. Ein leitfaden fur studierende, arzte und psychologen
. Berlin, Germany: Springer.
Jaspers K (1913b) Kausale und ‘verständliche’Zusammenhänge zwischen Schicksal und Psychose bei der Dementia praecox (Schizophrenie). Z Gesamte Neurol Psychiatr
. 14: 391–408. Translated in 2007.
Jaspers K (1963) General psychopathology. Translated from the German 7th edition by Hoenig J and Hamilton MH
. Manchester, England: Manchester University Press.
Jaspers K (1968) The phenomenological approach in psychopathology. Br J Psychiatry
. 114: 1313–1323.
Jaspers K (2007) Causal and ‘understandable’ relationships between events and psychosis in dementia praecox (schizophrenia). In Sass H (Ed), Anthology of German psychiatric texts
(pp 174–293). World Psychiatric Association. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/9780470684351.ch8/summary.
Kendell RE, Cooper JE, Gourlay AJ, Copeland JR, Sharpe L, Gurland BJ (1971) Diagnostic criteria of American and British psychiatrists. Arch Gen Psychiatry
. 25: 123–130.
Kendler KS, Muñoz RA, Murphy G (2010) The development of the Feighner criteria: A historical perspective. Am J Psychiatry
. 167: 134–142.
Kirkbright S (2004) Karl Jaspers: A biography. Navigations in truth
. New Haven, CT: Yale University Press.
Klerman GL (1978) The evolution of a scientific nosology. In Shershow JC (Ed), Schizophrenia: Science and practice
(pp 99–121). Cambridge, MA: Harvard University Press.
Kraepelin E (1920a) The German institute of psychiatric research. J Nerv Ment Dis
. 51: 505–513.
Kraepelin E (1920b) Die Erscheinungsformen des Irreseins. Z Gesamte Neurol Psychiatr
. 62: 1–29. Translated in 1992.
Kraepelin E (1992) The manifestations of insanity. Hist Psychiatry
. 4: 509–529.
Kramer M (1969) Cross-national study of diagnosis of the mental disorders: Origin of the problem. Am J Psychiatry
. 10 (suppl): 1–11.
Lewis A (1977) William Mayer-Gross: An appreciation. Psychol Med
. 7: 11–18.
Mayer-Gross W, Slater E, Roth M (1954) Clinical psychiatry
. London: Cassell & Co.
Mayer-Gross W, Slater E, Roth M (1960) Clinical psychiatry
(2nd ed). London: Cassell & Co.
McHugh P (1987) Psychiatry and its scientific relatives: “A little more than kin and less than kind”. J Nerv Ment Dis
. 175: 579–583.
McHugh P, Slavney PR (1998) The perspectives of psychiatry
(2nd ed). Baltimore: The Johns Hopkins University Press.
McHugh PR (2005) Striving for coherence: Psychiatry’s efforts over classification. JAMA
. 293: 2526–2528.
McHugh PR (2012) Rendering mental disorders intelligible: Addressing psychiatry’s urgent challenge. In Kendler KS, Parnas J (Eds), Philosophical issues in psychiatry II. Nosology: International perspectives in philosophy and psychiatry
(pp 269–280). Oxford, England: Oxford University Press.
McHugh PR, Slavney PR (1982) Methods of reasoning in psychopathology: Conflict and resolution. Compr Psychiatry
. 23: 197–215.
McNally K (2009) Eugene Bleuler’s four As. Hist Psychol
. 12: 43–59.
Mundt C (1993) Karl Jaspers. Am J Psychiatry
. 150: 1244–1245.
Oliver HH (1988) Karl Jaspers and modern physics. In Ehrlich LH, Wisser R (Eds), Karl Jaspers today: Philosophy at the threshold of the future
(pp 111–131). Washington, DC: Center for Advanced Research in Phenomenology & University Press of America.
Peters UH (1996) The emigration of German psychiatrists to Britain. In Freeman H, Berrios GE (Eds), 150 years of British psychiatry. The aftermath
(Vol 2, pp 565–580). London: Athlone.
Robins E, Guze SB (1970) Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. Am J Psychiatry
. 126: 983–987.
Rosenhan DL (1973) On being sane in insane places. Science
. 179: 250–258.
Schneider K (1959) Clinical psychopathology
. London: Grune & Stratten.
Schwartz MA, Wiggins OP (1986) Systems and the structuring of meaning: Contributions to a biopsychosocial medicine. Am J Psychiatry
. 143: 1213–1221.
Shepherd M (1982) Books reconsidered. Karl Jaspers: General psychopathology. Br J Psychiatry
. 141: 310–312.
Sims A (2013) Reflection. Karl Jaspers. Br J Psychiatry
. 202: 4.
Slater E, Roth M (1977) Clinical psychiatry
(3rd ed). London: Baillare Tindall.
Slavney PR, McHugh PR (1987) Explanation and understanding. In Slavney PR, McHugh PR (Eds), Psychiatric polarities
(pp 29–44). Baltimore: The Johns Hopkins University Press.
Spitzer RL, Andreasen NC, Endicott J (1978a) Schizophrenia and other psychotic disorders in DSM-III
. Schizophr Bull
. 4: 489–510.
Spitzer RL, Endicott J, Robins E (1975) Research diagnostic criteria for a selected group of functional disorders
. New York: New York Psychiatric Institute.
Spitzer RL, Endicott J, Robins E (1978b) Research diagnostic criteria: Rationale and reliability. Arch Gen Psychiatry
. 35: 773–782.
Trethowan WK (1963) Book reviews. General Psychopathology
by Karl Jaspers. Br J Psychiatry
. 109: 698–699.
Tsuang MT (1999) George Winokur, M.D 1925-1996. Am J Psychiatry
. 156: 465–466.
Weber MM, Engstrom EJ (1997) Kraepelin’s ‘diagnostic cards’: the confluence of clinical research and preconceived categories. Hist Psychiatry
. 8: 375–385.
Wilson M (1993) DSM-III
and the transformation of American psychiatry: A history. Am J Psychiatry
. 150: 399–410.
Wing JK (1983) Use and misuse of the PSE. Br J Psychiatry
. 143: 111.
Wing JK, Birley JL, Cooper JE, Graham P, Isaacs AD (1967) Reliability of a procedure for measuring and classifying “present psychiatric state”. Br J Psychiatry
. 113: 499–515.
Wing JK, Cooper JE, Sartorius N (1974) Measurement and classification of psychiatric symptoms: An instruction manual for the PSE and CATEGO program
. Cambridge, UK: Cambridge University Press.
Zubin J (1969) Cross-national study of diagnosis of the mental disorders: Methodology and planning. Am J Psychiatry
. 10 (suppl): 12–20.