Skip Navigation LinksHome > April 2012 - Volume 200 - Issue 4 > Patterns of Autobiographical Memory in Bipolar Disorder Exam...
Journal of Nervous & Mental Disease:
doi: 10.1097/NMD.0b013e31824ceef7
Original Articles

Patterns of Autobiographical Memory in Bipolar Disorder Examined by Psychometric and Functional Neuroimaging Methods

Oertel-Knöchel, Viola PhD*; Reinke, Britta MSc*; Hornung, Alexandra*; Knöchel, Christian*; Matura, Silke MSc*; Knopf, Monika; Prvulovic, David PhD*; O’Dwyer, Laurence PhD*; Lindner, Michael PhD*; Rau, Alexandra*; Hampel, Harald*; Haenschel, Corinna PhD*‡; Linden, David E.J.§∥

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Abstract: This is the first study to combine psychometric and functional neuroimaging methods to study altered patterns of autobiographical memory in bipolar disorder (BD). All participants were interviewed with an expanded version of the Bielefelder Autobiographical Memory Inventory (Bielefelder Autobiographisches Gedächtnis Inventar 2004;Lisse: Swets and Zeitlinger). We then acquired functional magnetic resonance imaging data during a task of individually designed autobiographical recall. Compared with healthy controls, BD patients reported a stronger emotionality of autobiographical memories and more frequent recollections of autobiographical events during their everyday life. Furthermore, they failed to deactivate areas in the cuneus and lingual gyrus and showed decreased activation in the inferior frontal and precentral areas compared with the control group. More frequent intrusions from a person’s past, which had a neural correlate in the lack of deactivation in some default mode network areas in BD patients, may contribute to manic or depressive symptoms.

© 2012 Lippincott Williams & Wilkins, Inc.


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