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Kay, Gary PhD
Georgetown University Medical Center, New Orleans, LA
This presentation begins with a discussion of the methodologies used to investigate CNS depressant effects of antihistamines, including self-report methods, physiological measures, and performance methods such as cognitive and psychomotor testing, and the use of job, driving, and classroom simulations. The sensitivity of these methods will be compared and the importance of evaluating sedation effects with all three methods will be stressed. Participants will be familiarized with the impact of sedating antihistamines on work-related injuries, classroom performance, and driving skills. To demonstrate the methodologies currently used to assess sedation, the presenter will describe two recently published studies. The first study to be discussed was an investigation of acute and steady-state effects of diphenhydramine and loratadine on self-reported mood, cognitive performance, and psychomotor performance. The second study investigated the impact of the effects of nighttime administration of chlorpheniramine (8 mg and 12 mg) in combination with daytime administration of terfenadine (AM-PM dosing) on daytime sleepiness and level of alertness. These studies demonstrate that sedating antihistamines negatively affect mood, sleepiness, alertness, cognitive, and psychomotor performance.
American Occupational Health Conference (AOHC); April 28-30, 1999, New Orleans, LA
Wednesday, April 28; 1:30pm-5:00pm;
© 1999 Lippincott Williams & Wilkins, Inc.
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