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Occupational and Environmental Risk Factors for Chronic Fibrosing idiopathic Interstitial Pneumonia in South Korea

Kim, Se Yeong MD, PhD; Kang, Dong Mug MD, PhD; Lee, Hyun Kyung MD, PhD; Kim, Kun Hyung MD PhD; Choi, Junghye MD

Journal of Occupational and Environmental Medicine: November 2017 - Volume 59 - Issue 11 - p e221–e226
doi: 10.1097/JOM.0000000000001153
Original Articles

Objective: We studied the association of occupational and environmental agents with chronic fibrosing idiopathic interstitial pneumonia (IIP) in South Korea.

Methods: We recruited 92 patients with chronic fibrosing IIP and 92 matched controls who had normal chest radiograph findings by age and gender. We used a structured exposure questionnaire to evaluate potential occupational and environmental risk factors for chronic fibrosing IIP, with adjustments for age, smoking, and clinical risk factors.

Results: We used conditional logistic regression models to analyze associations with chronic fibrosing IIP adjusted for age, smoking and clinical risk factors. Exposure to stone, sand, or silica significantly increased the risk of chronic fibrosing IIP (odds ratio = 5.01; 95% confidence interval, 1.07–24.21)

Conclusions: Our findings indicate that exposure to stone, sand, and silica might constitute a risk factor for developing chronic fibrosing IIP in the Korean population.

Busan Workers’ Health Center, Korea & Pusan National University (Dr Kim), Occupational and Environmental Medicine, Pusan National University Yangsan Hospital (Dr Kang), Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital (Dr Lee), Department of Occupational and Environmental Medicine & Institute of Environmental and Occupational Medicine, Pusan Paik Hospital, Inje University (Drs Kim, Choi), Gyeongsangnam-do, South Korea.

Address correspondence to: Dong Mug Kang, MD, PhD, Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, 1st floor, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, South Korea (

This study was supported by 2014 Academic Award of The Korean Society of Occupational Asthma and Lung Diseases.

The authors report no conflict of interest.

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Copyright © 2017 by the American College of Occupational and Environmental Medicine