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Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens.

Jurewicz, Joanna PhD; Radwan, Michal PhD; Wielgomas, Bartosz PhD; Dziewirska, Emila MSc; Karwacka, Anetta MD; Klimowska, Anna MSc; Kaluzny, Pawel PhD; Radwan, Pawel PhD; Bochenek, Michal PhD; Hanke, Wojciech MD, PhD
Journal of Occupational & Environmental Medicine: Post Author Corrections: July 7, 2017
doi: 10.1097/JOM.0000000000001106
Original Article: PDF Only

Objective: The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol].

Methods: Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300 mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method. Participants were interviewed and also provided a semen, saliva, and blood samples.

Results: Urinary parabens concentrations were significantly associated with an increase in the percentage of sperm with abnormal morphology, in sperm with high DNA stainability and a decrease in the percentage of motility and testosterone level.

Conclusions: This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.

Copyright (C) 2017 by the American College of Occupational and Environmental Medicine