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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0000000000000167
Original Articles

Prenatal Exposure to Air Toxics and Risk of Wilms' Tumor in 0- to 5-Year-Old Children

Shrestha, Anshu PhD; Ritz, Beate PhD; Wilhelm, Michelle PhD; Qiu, Jiaheng MS; Cockburn, Myles PhD; Heck, Julia E. PhD

Continued Medical Education
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Objective: To study prenatal air toxic exposure and Wilms' tumor in children.

Methods: We identified 337 Wilms' tumor cases among children younger than 6 years (1988 to 2008) from the California Cancer Registry, randomly selected 96,514 controls from California birth rolls in 20:1 ratio matched to all cancer cases, then linked birth addresses to air monitors within 15 miles to assess exposures. Multiple logistic regressions were applied to estimate effects.

Results: Children prenatally exposed to formaldehyde, polycyclic aromatic hydrocarbons, perchloroethylene, or acetaldehyde in the third trimester had an increased odds of Wilms' tumor per interquartile increase in concentration (odds ratio [95% confidence interval]: 1.28 [1.12 to 1.45], 1.10 [0.99 to 1.22], 1.09 [1.00 to 1.18], 1.25 [1.07 to 1.45], respectively).

Conclusions: We found positive associations for four air toxics. This is the first study of this kind. Future studies are needed to confirm our findings.

Copyright © 2014 by the American College of Occupational and Environmental Medicine


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