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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0000000000000061
Original Articles

Relationship Between Welding Fume Concentration and Systemic Inflammation After Controlled Exposure of Human Subjects With Welding Fumes From Metal Inert Gas Brazing of Zinc-Coated Materials

Brand, Peter PhD; Bauer, Marcus MD; Gube, Monika MD; Lenz, Klaus Dipl Ing; Reisgen, Uwe Dr Ing; Spiegel-Ciobanu, Vilia Elena Dr Ing; Kraus, Thomas MD

Continued Medical Education
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Abstract

Objectives: It has been shown that exposure of subjects to emissions from a metal inert gas (MIG) brazing process of zinc-coated material led to an increase of high-sensitivity C-reactive protein (hsCRP) in the blood. In this study, the no-observed-effect level (NOEL) for such emissions was assessed.

Methods: Twelve healthy subjects were exposed for 6 hours to different concentrations of MIG brazing fumes under controlled conditions. High-sensitivity C-reactive protein was measured in the blood.

Results: For welding fumes containing 1.20 and 1.50 mg m−3 zinc, high-sensitivity C-reactive protein was increased the day after exposure. For 0.90 mg m−3 zinc, no increase was detected.

Conclusions: These data indicate that the no-observed-effect level for emissions from a MIG brazing process of zinc-coated material in respect to systemic inflammation is found for welding fumes with zinc concentrations between 0.90 and 1.20 mg m−3.

Copyright © 2014 by the American College of Occupational and Environmental Medicine

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