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Occupation and Head and Neck Cancer Risk in Men: Results From the ICARE Study, a French Population-Based Case–Control Study

Paget-Bailly, Sophie PhD; Guida, Florence PharmD, PhD; Carton, Matthieu MD; Menvielle, Gwenn PhD; Radoï, Loredana DDS, PhD; Cyr, Diane MS; Schmaus, Annie MS; Cénée, Sylvie MS; Papadopoulos, Alexandra PhD; Févotte, Joëlle MS; Pilorget, Corinne PhD; Velten, Michel MD; Guizard, Anne-Valérie MD; Stücker, Isabelle PhD; Luce, Danièle PhD

Journal of Occupational and Environmental Medicine: September 2013 - Volume 55 - Issue 9 - p 1065–1073
doi: 10.1097/JOM.0b013e318298fae4
Original Articles

Objective: To investigate the associations between occupations and head and neck (HN) cancer risk in men.

Methods: ICARE is a French population-based case–control study on HN cancer. Analyses included 1833 cases and 2747 controls. Complete occupational history was collected. Odds ratios (ORs) were estimated for occupations and industries ever held and according to duration of employment.

Results: Elevated ORs, increasing with duration of employment, were observed for several occupations, including cleaners (OR = 1.7; 95% confidence interval [CI], 1.0 to 2.8), launderers (OR = 6.8; CI, 1.3 to 34.4), firefighters (OR = 3.9; CI, 1.4 to 11.2), several agricultural occupations, welders (OR = 1.9; CI, 1.3 to 2.8), structural metal preparers and erectors (OR = 2.1; CI, 1.2 to 3.7), rubber workers (OR = 2.0; CI, 1.0 to 3.9), several construction occupations, and material-handling equipment operators (OR = 1.8; CI, 1.1 to 2.9). Analyses by industry corroborated these findings.

Conclusions: These results confirmed the role of occupational exposures in HN cancer.

From the Inserm, Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Occupational and Social Determinants of Health Team (Dr Paget-Bailey, Dr Carton, Dr Menvielle, Dr Radoï, Ms Cyr, Ms Schmaus, and Dr Luce) and Environmental Epidemiology of Cancer Team (Dr Guida, Ms Cénée, Dr Papadopoulos, and Dr Stücker), Villejuif, France; University Versailles St-Quentin (Dr Paget-Bailly, Dr Carton, Dr Menvielle, Dr Radoï, Ms Cyr, Ms Schmaus, and Dr Luce), Versailles, France; University Paris-Sud (Dr Guida, Ms Cénée, Dr Papadopoulos, and Dr Stücker), UMRS1018, Villejuif, France; University Lyon 1 (Ms Févotte and Dr Pilorget), Unité mixte de recherche épidémiologique et de surveillance en transport, travail et environment (Umrestte), Lyon, France; Institut de Veille Sanitaire (Dr Pilorget), Département Santé Travail, Saint Maurice, France; Bas-Rhin Cancer Registry (Dr Velten), Strasbourg, France; Calvados Cancer Registry (Dr Guizard), Caen, France.

Address correspondence to: Danièle Luce, PhD, Hôpital Paul Brousse, Bâtiment 15/16, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France (daniele.luce@inserm.fr).

The ICARE study was supported by the French National Research Agency (ANR); the French National Cancer Institute (INCA); the French Agency for Food, Environmental and Occupational Health and Safety (ANSES); the French Institute for Public Health Surveillance (InVS); Fondation pour la Recherche Médicale (FRM); Fondation de France; Association pour la Recherche sur le Cancer (ARC); Ministry of Labour (Direction Générale du Travail); Ministry of Health (Direction Générale de la Santé). Sophie Paget-Bailly received funds from the Health Environment Toxicology program (SEnT) of the Ile-de France regional council (Conseil regional d'Ile de France) and from La Ligue contre le cancer for this work.

The authors declare that they have no conflicts of interest.

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Copyright © 2013 by the American College of Occupational and Environmental Medicine