Skip Navigation LinksHome > August 2013 - Volume 55 - Issue 8 > Occupational Exposure to Chlorinated and Petroleum Solvents...
Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e3182941a1c
Original Articles

Occupational Exposure to Chlorinated and Petroleum Solvents and Mycosis Fungoides

Morales-Suárez-Varela, Maria M. MD, PhD; Olsen, Jorn MD, PhD; Villeneuve, Sara; Johansen, Preben MD, PhD; Kaerlev, Linda MD, PhD; Llopis-González, Agustin MD, PhD; Wingren, Gun MD, PhD; Hardell, Lennart MD, PhD; Ahrens, Wolfgang MD, PhD; Stang, Andreas MD, PhD; Merletti, Franco MD, PhD; Gorini, Giuseppe MD, PhD; Aurrekoetxea, Juan José MD, PhD; Févotte, Joëlle MD, PhD; Cyr, Diane MD, PhD; Guénel, Pascal MD, PhD

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Abstract

Objective: To evaluate the potential association between occupational exposure to chlorinated and petroleum solvents and mycosis fungoides (MF).

Methods: A questionnaire on lifetime job history was administered to 100 patients diagnosed with MF and 2846 controls. Odds ratios (ORs) were calculated as the measure of the association between exposure to each specific solvent and MF.

Results: In the total sample and in men, cases and controls did not differ in relation to exposure to any of the solvents studied. In women, an association with MF was seen for the highest level of estimated exposure to perchloroethylene (OR = 11.38; 95% confidence interval: 1.04 to 124.85) and for exposure less than the median to kerosene/fuel/gasoil (OR = 8.53; 95% confidence interval: 1.11 to 65.62).

Conclusions: These results do not provide conclusive evidence that exposure to solvents may increase risk of MF because they were not found in men.

Copyright © 2013 by the American College of Occupational and Environmental Medicine

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