Skip Navigation LinksHome > August 2013 - Volume 55 - Issue 8 > Challenge Exposure to Isocyanates Induces Changes in Nasal P...
Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318293aef9
Original Articles

Challenge Exposure to Isocyanates Induces Changes in Nasal Patency in Patients Reporting Work-Related Respiratory Symptoms

Castano, Roberto MD, PhD; Johnson, Victor J. PhD; Cartier, Andre MD

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Objective: To examine the utility of specific inhalation challenge (SIC) in assessing the nasal congestive response to isocyanate exposure.

Methods: Nine patients complaining of work-related respiratory symptoms underwent SIC with exposure to isocyanate for 4 and 120 minutes on different days. Nasal volume was monitored by acoustic rhinometry and nasal congestion by the visual analogue scale (VAS) for up to 6 hours.

Results: The 4-minute isocyanate SIC induced a nonsignificant fall in nasal volume and no increase in the VAS score. The 120-minute isocyanate SIC induced a significant fall in nasal volume at 15, 30, and 60 minutes postchallenge that was associated with a significant increase in the VAS score at 15 and 30 minutes postchallenge.

Conclusions: SIC appears useful to assess changes in nasal patency after exposure to isocyanate. Exposure to isocyanates can induce nasal congestion that can be objectively monitored during SIC.

Copyright © 2013 by the American College of Occupational and Environmental Medicine


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