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Risk of Lung Cancer Associated With Occupational Exposure to Mineral Wools: Updating Knowledge From a French Population-Based Case–Control Study, the ICARE Study

Guida, Florence PharmD; Paget-Bailly, Sophie PhD; Lamkarkach, Farida MS; Gaye, Oumar MS; Ducamp, Stéphane MS; Menvielle, Gwenn PhD; Papadopoulos, Alexandra PhD; Matrat, Mireille MD; Févotte, Joëlle MS; Cénée, Sylvie MS; Cyr, Diane MS; Schmaus, Annie MS; Carton, Matthieu MD; Radoï, Loredana DMD; Lapôtre-Ledoux, Bénédicte MD; Molinié, Florence MD; Luce, Danièle PhD; Stücker, Isabelle PhD

Journal of Occupational and Environmental Medicine: July 2013 - Volume 55 - Issue 7 - p 786–795
doi: 10.1097/JOM.0b013e318289ee8b
Original Articles

Objectives: To assess the risk of lung cancer associated with exposure to mineral wools (MWs), while taking into account smoking, asbestos, and crystalline silica exposures.

Methods: The analyses were restricted to men (1350 cases and 1912 controls). Lifelong occupational history was collected. MWs and asbestos exposures were assessed, using task-exposure matrices and silica exposure, a job-exposure matrix.

Results: We observed consistent not-significant increased risks of lung cancer of the same order of magnitude among workers exposed to high levels of MWs (odds ratio, 1.4; 95% confidence interval: 0.9 to 2.2; for highest quartile of the Cumulative Exposure Index).

Conclusions: These results do not allow to draw firm conclusion about a carcinogenic effect of MWs on the lung, but they cannot exclude it. Given the high number of potentially exposed workers, it will be necessary to replicate them in a future further removed from the asbestos ban.

From UMRS 1018, the Environmental Epidemiology of Cancer Team (Drs Guida, Papadopoulos, and Stücker, Ms Lamkarkach, Ms Gaye, and Ms Cénée) and Epidemiology of Occupational and Social Determinants of Health Team (Drs Paget-Bailly, Menvielle, Carton, Radoï, and Luce, Ms Cyr, and Ms Schmaus), the Inserm, CESP Centre for Research in Epidemiology and Population Health, Villejuif, France; University Paris-Sud, UMRS 1018 (Drs Guida, Papadopoulos, and Stücker, Ms Lamkarkach, Ms Gaye, and Ms Cénée), Villejuif, France; Inserms, CESP Centre for Research in Epidemiology and Population Health, UMRS 1018, Epidemiology of Occupational and Social Determinants of Health Team (Drs Paget-Bailly, Menvielle, Carton, Radoï, and Luce, Ms Cyr, and Ms Schmaus), Villejuif, France; University of Versailles St-Quentin, UMRS 1018 (Drs Paget-Bailly, Menvielle, Carton, Radoï, and Luce, Ms Cyr, and Ms Schmaus), Villejuif, France; Département Santé Travail (Ms Ducamp), Institut de Veille Sanitaire, Saint Maurice, France; Équipe Associée en Santé Travail- Essat (Ms Ducamp), Laboratoire Santé, travail, environnement (Equipe d'acceuil EA 3672), Institut de Santé Publique d'Epidémiologie et de Développement, Bordeaux, France; Inserm, U955 (Dr Matrat), Faculty of medicine (Dr Matrat), University Paris Est-Créteil Faculty of medicine, Institut Fédératif de recherche IFR 10, and Centre Hospitalier Intercommunal (Dr Matrat), service de Pneumologie et de Pathologie Professionnelle, Créteil, France; Unité mixte de recherche épidémiologique et de surveillance en transport, travail et environnement (Ms Févotte), University Claude Bernard, Lyon 1, France; Somme Cancer Registry (Dr Lapôtre-Ledoux), Amiens, France; and Loire-Atlantique et Vendée Cancer Registry (Dr Molinié), Nantes, France.

Address correspondence to: Isabelle Stücker, PhD, INSERM, UMRS1018, CESP, Equipe 6, Hôpital Paul-Brousse, Bâtiment 15/16, 16 Av. Paul Vaillant Couturier, F-94807, Villejuif, France (isabelle.stucker@inserm.fr).

This work was supported by the French Agency of Health Security (ANSES), the Fondation de France, the French National Research Agency (ANR), the National Institute of Cancer (INCA), the Foundation for Medical Research (FRM), the French Institute for Public Health Surveillance (Institut de Veille Sanitaire), the Health Ministry (DGS), the Organization for the Research on Cancer (ARC), and the French Ministry of Work, Solidarity and Public Function (DGT).

The authors declare no conflicts of interest.

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Copyright © 2013 by the American College of Occupational and Environmental Medicine