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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318289ee8b
Original Articles

Risk of Lung Cancer Associated With Occupational Exposure to Mineral Wools: Updating Knowledge From a French Population-Based Case–Control Study, the ICARE Study

Guida, Florence PharmD; Paget-Bailly, Sophie PhD; Lamkarkach, Farida MS; Gaye, Oumar MS; Ducamp, Stéphane MS; Menvielle, Gwenn PhD; Papadopoulos, Alexandra PhD; Matrat, Mireille MD; Févotte, Joëlle MS; Cénée, Sylvie MS; Cyr, Diane MS; Schmaus, Annie MS; Carton, Matthieu MD; Radoï, Loredana DMD; Lapôtre-Ledoux, Bénédicte MD; Molinié, Florence MD; Luce, Danièle PhD; Stücker, Isabelle PhD

Supplemental Author Material
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Objectives: To assess the risk of lung cancer associated with exposure to mineral wools (MWs), while taking into account smoking, asbestos, and crystalline silica exposures.

Methods: The analyses were restricted to men (1350 cases and 1912 controls). Lifelong occupational history was collected. MWs and asbestos exposures were assessed, using task-exposure matrices and silica exposure, a job-exposure matrix.

Results: We observed consistent not-significant increased risks of lung cancer of the same order of magnitude among workers exposed to high levels of MWs (odds ratio, 1.4; 95% confidence interval: 0.9 to 2.2; for highest quartile of the Cumulative Exposure Index).

Conclusions: These results do not allow to draw firm conclusion about a carcinogenic effect of MWs on the lung, but they cannot exclude it. Given the high number of potentially exposed workers, it will be necessary to replicate them in a future further removed from the asbestos ban.

Copyright © 2013 by the American College of Occupational and Environmental Medicine


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