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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e3182871583
Original Articles

Long-Term Health Experience of Jet Engine Manufacturing Workers: VIII. Glioblastoma Incidence in Relation to Workplace Experiences With Parts and Processes

Marsh, Gary M. PhD; Youk, Ada O. PhD; Buchanich, Jeanine M. PhD; Downing, Sarah BS; Kennedy, Kathleen J. MS; Esmen, Nurtan A. PhD; Hancock, Roger P. MCE; Lacey, Steven E. PhD; Pierce, Jennifer S. PhD; Fleissner, Mary Lou DrPH

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Abstract

Objective: To determine whether glioblastoma (GB) incidence rates among jet engine manufacturing workers were associated with workplace experiences with specific parts produced and processes performed.

Methods: Subjects were 210,784 workers employed between 1952 and 2001. We conducted nested case-control and cohort incidence studies with focus on 277 GB cases. We estimated time experienced with 16 part families, 4 process categories, and 32 concurrent part-process combinations with 20 or more GB cases.

Results: In both the cohort and case-control studies, none of the part families, process categories, or both considered was associated with increased GB risk.

Conclusions: If not due to chance alone, the not statistically significantly elevated GB rates in the North Haven plant may reflect external occupational factors or nonoccupational factors unmeasured in the current evaluation.

©2013The American College of Occupational and Environmental Medicine

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