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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318278272f
Original Articles

Association of Aryl Hydrocarbon Receptor Gene Polymorphism With the Neurobehavioral Function and Autonomic Nervous System Function Changes Induced by Benzo[a]Pyrene Exposure in Coke Oven Workers

Zhang, Hongmei MD, PhD; Nie, Jisheng MD, PhD; Li, Xin MD; Niu, Qiao MD, PhD

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Objective: To analyze the association of aryl hydrocarbon receptor (AhR) gene polymorphism and the neurotoxicity induced by benzo[a]pyrene (B[a]P) in coke oven workers.

Methods: Subjects, 214 coke oven workers and 81 controls, were detected for neurobehavioral function and autonomic nervous system (ANS) function. Airborne B[a]P concentration, urinary 1-hydroxypyrene level, and AhR gene polymorphisms were determined and analyzed for their association with B[a]P neurotoxicity.

Results: Neurobehavioral function and ANS function were significantly decreased and dependent on B[a]P dose. The AhR GG, GA, and AA genotypes in G1661A fitted the Hardy-Weinberg equation, whereas C1549T and G1708A gene mutants were not detected. Indices indicating neurotoxicity showed no significant difference among individuals with AA, GG, or GA genotype except for the confusion-bewilderment (P > 0.05).

Conclusion: The AhR gene polymorphism is not thought to correlate with B[a]P neurotoxicity among coke oven workers.

©2013The American College of Occupational and Environmental Medicine


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