Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants.
To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise.
We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area.
Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein–1, and interleukin-6, but did not change coagulation tendency or heart rate variability.
Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small.
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From the Human Exposure Laboratory, Division of Occupational and Environmental Medicine (Mr Donde, Mr Wong, Ms Frelinger, and Drs Power, Balmes, and Arjomandi); Division of Pulmonary and Critical Care Medicine, Department of Medicine (Ms Frelinger and Drs Balmes and Arjomandi), University of California San Francisco, Calif.; School of Public Health (Dr Balmes), University of California Berkeley, Calif.; and Pulmonary Research Group, Veterans Affairs Medical Center (Ms Frelinger and Dr Arjomandi), San Francisco, Calif.
Address correspondence to: Mehrdad Arjomandi, MD, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco Veterans Affairs Medical Center, Bldg 203, Room 3A-128, Mailstop 111-D, 4150 Clement St, San Francisco, CA 94121 (firstname.lastname@example.org).
This study was funded by California Air Resources Board, NIH/NHLBI K23 HL083099, the Northern California Institute for Research and Education, and the University of California San Francisco Cardiovascular Research Institute Faculty Development Funds.
Disclosure: The authors declare no conflict of interest.
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