Skip Navigation LinksHome > April 2012 - Volume 54 - Issue 4 > Effects of Exercise on Systemic Inflammatory, Coagulatory, a...
Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318246f1d4
Original Articles

Effects of Exercise on Systemic Inflammatory, Coagulatory, and Cardiac Autonomic Parameters in an Inhalational Exposure Study

Donde, Aneesh BS; Wong, Hofer BS; Frelinger, Jessica BS; Power, Karron MD; Balmes, John R. MD; Arjomandi, Mehrdad MD

Supplemental Author Material
Collapse Box


Background: Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants.

Objective: To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise.

Methods: We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area.

Results: Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein–1, and interleukin-6, but did not change coagulation tendency or heart rate variability.

Conclusion: Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small.

©2012The American College of Occupational and Environmental Medicine


Article Tools


Article Level Metrics